My Normal Human Cells have changed their morphology. What could be the reason?
A change in cell morphology can have several biological or technical causes and does not necessarily indicate a problem with the cells themselves.
Common reasons include:
Common reasons include:
- Change in culture medium or supplements: Switching media, using incorrect supplements, or changes in serum concentration can alter cell morphology.
- Cross‑contamination with another cell type: Even low‑level contamination can lead to the appearance of cells with a different morphology.
- Differentiation: Some Normal Human Cells may spontaneously differentiate under certain culture conditions, resulting in altered shape and growth behavior.
- Senescence: As primary cells age in vitro, they may enter senescence, which is often accompanied by noticeable morphological changes (e.g. enlarged, flattened cells).
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Primary Human Keratinocytes isolated in serum-free and BPE-free Keratinocyte Growth Medium 3. Available from juvenile foreskin or adult skin from single or pooled donors.
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