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Human primary-cell models can help capture the immune–tissue interactions that drive autoimmune disease in vitro. Explore how cell type, donor background, disease status, HLA context, and model design influence experimental relevance, and what to consider when building an autoimmune model.

Stem cell therapy workflows need more than a successful research protocol as they move toward clinical translation. In this expert interview, Dr. Hagen Wieland discusses how early decisions around culture conditions, raw materials, scale-up, documentation, and cryopreservation can influence reproducibility, regulatory readiness, and later GMP transition.

Human preadipocyte cell models are widely used to study adipogenesis, obesity, insulin resistance, and metabolic disease mechanisms in vitro. However, assay outcomes can vary depending on donor background, adipose depot origin, differentiation capacity, and culture conditions.

Stem cell cryopreservation is the controlled freezing of stem cells to preserve their viability and function for future research or therapeutic use. It is one of the most important steps in cell-based research or therapy workflows. This blog article explores the main challenges of stem cell cryopreservation and practical steps to improve cell viability.

Choosing the right cell detachment method is essential for maintaining cell viability, functionality, and reproducibility. From classical trypsinization to gentler enzymatic and non-enzymatic alternatives, each approach comes with specific advantages and limitations. This guide helps you navigate key decision criteria to select the most suitable method for your adherent cells.

CD34⁺ hematopoietic progenitor cells (HPCs) are the proliferative intermediates that drive day-to-day renewal of the blood and immune cells. Arising from hematopoietic stem cells, HPCs have limited self-renewal but a robust capacity to expand and differentiate into lineage-restricted myeloid and lymphoid progeny. Read on to learn about the role of CD34⁺ HPCs and other CD34+ populations and how to expand them.

In this interview with RegMedNet, our experts share how allogeneic cell therapies are advancing toward clinical application, highlighting key considerations for cell quality, scalable production, and GMP compliance.

Throughout 2025, our products were featured in a wide range of research areas, such as oncology, immunology, and cardiovascular research. This blog post highlights a selection of recent scientific papers utilizing our products. It illustrates how researchers apply physiological relevant cell models and defined culture systems to investigate disease mechanisms, therapeutic strategies, and human biological function. These references provide a year-end snapshot of how scientists integrate our products into experimental workflows spanning basic research through translational models.

Traditional cell culture systems often fall short of replicating the complex environment of the human airway, limiting their predictive power in respiratory research. To address these limitations, researchers increasingly rely on physiologically relevant in vitro models that better reflect human airway biology. Among these, air-liquid interface (ALI) culture bridges the gap between simple two-dimensional systems and complex animal models, offering a human-based approach for studying respiratory function and disease in vitro.

Implementing a qualified supply chain for GMP-compliant cell culture products is a crucial step toward meeting the highest quality standards. In this interview with RegMedNet, our experts share insights into the supply chain requirements that must comply with GMP regulations for cell culture products.

Not all cancer cells within a single tumor have the same characteristics. The tumor microenvironment contains various subsets of cancer cells. The characteristics of each subgroup can influence tumor growth, metastasis, and treatment resistance. Read on to learn how these cellular differences affect cancer progression and treatment outcomes.

The traditional view of macrophages as ‘good’ or ‘bad’ immune cells has become outdated. Recent studies have shown that macrophage plasticity encompasses a complex spectrum of activation states, each of which plays an important role in health and disease. In this article, we discuss the latest understanding of macrophage polarization, the challenges in standardizing nomenclature, and why standardization is important for the development of new therapeutic approaches.