Characterization of mesenchymal stem cells (MSCs) is vital for their successful application in regenerative medicine. These multipotent cells can differentiate into several cell types, making them a promising therapeutic option for various diseases. In our blog post, we discuss the importance of MSC characterization in ensuring standardized and reproducible cell isolation,…
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Stem cell immunotherapy: Harnessing the immune system
Imagine a future where diseases once considered incurable are now within reach of treatment. This is the promise of stem cell immunotherapy, a rapidly evolving approach that harnesses the unique properties of pluripotent cells to revolutionize medical treatments.1 From autoimmune diseases to cancer, the potential of stem cell immunotherapy is vast and transformative. …
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Stem cell therapy scientist: Finding inspiration outside his comfort zone
Crossing the border between medical and biomechanical research fuels the research of stem cell specialist Dr. Diego Correa. We talked to the Colombian-born stem cell scientist, a former clinician with training in mechanical engineering, about his studies with mesenchymal stem cells and their potential clinical applications in cell-based therapy. Soon Correa is going to publish what he believes will be his most important contribution to this field….
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Mesenchymal Stem Cells: Challenges and chances in cancer therapy
As the potential for using mesenchymal stem cells in cancer therapy grows, understanding the biology behind them can help inform and inspire innovative cancer therapies. Using high quality media and culture kits will increase the efficiency and usability of these highly demanded cells.
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Why you should know your human mesenchymal stem cells inside out
Doctors, and patients with chronic diseases, are putting hope into new findings in regenerative medicine that are based on mesenchymal stem cell (MSC) research. As promising as some published results sound, they might be not reproducible – simply due to insufficient authentication and poor handling of cell cultures. Rigorous validation of cell identity is crucial for working with human mesenchymal stem cells – and,…
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Mesenchymal stem cells: why optimizing manufacturing processes is key for a successful application
Mesenchymal stem cells (MSCs) are the up-and-coming stars of cell therapy. They are able to differentiate, are very adaptable and can reduce inflammation, making them ideal for regenerative medicine approaches. But the demand for MSCs is far greater than supply. Pharmaceutical companies are racing to produce commercial-scale quantities of MSCs while guaranteeing quality standards….
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From disease to healing: Exploring the roles of pericytes
They are multipotent, interact closely with endothelial cells, and are involved in immunosurveillance: the heterogeneous group of pericytes. These cells build the wall of blood vessels, and play a crucial role in the formation and maintenance of the vasculature. Due to their involvement in various pathophysiologies such as tumor angiogenesis, scientists are beginning to exploit their potential for therapeutic approaches….
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Introducing a novel high throughput 3D wound healing model
Non-healing wounds continue to cause significant patient burden. This blog details a novel 3D wound healing model that promises to facilitate the development of new treatments to promote wound healing.
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Branching out: In vitro angiogenesis advancements
In this interview with RegMedNet, our expert, Iris Bischoff-Kont, discusses the latest advancements in angiogenesis research and their potential applications in regenerative medicine. Dr Bischoff-Kont also explores the challenges faced in translating angiogenesis research findings into clinical therapies and the importance of understanding the crosstalk between angiogenesis and other processes like inflammation….
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Antibiotics in Cell Culture: Friend or Enemy?
Antibiotics are routinely used in cell cultures to prevent bacterial infections. But there are side effects: Studies show that they impair cell growth and differentiation. With good laboratory practice, the use of antibiotics is unnecessary.
A cell culture is a world of its own. The culture dish contains nutrients within the media that cells need to thrive and prosper….
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Endothelial to mesenchymal transition: Beyond blood vessels
Endothelial to mesenchymal transition (EndMT) is a complex biological process that is essential for various physiological functions, from embryonic development to tissue repair.1 But what happens when the mechanisms underlying EndMT are deregulated? In this article, we explore the intricacies of EndMT, discussing its mechanisms, role in health and disease, and therapeutic potential….
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Scaling up from 2D monolayers to complex 3D cell cultures
Using three-dimensional cell cultures is more popular today than ever. Yet as the complexity of cell culture increases – from 2D cell culture, spheroids, 3D models up to organoids – so do the variables. This means you should plan carefully before advancing from 2D to 3D cell culture. Keeping several key factors in mind,…
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