Advancing cancer treatment: New eBook on adoptive cell therapies for solid tumors

Adoptive cell therapy offers promise for the treatment of cancer through the use of engineered immune cells to target cancer cells. Although this approach has been successful in blood cancers, its application in solid tumors presents challenges, including immunosuppressive tumor microenvironments and limited immune cell infiltration. 

Our latest eBook, created in collaboration with RegMedNet, explores cutting-edge research and clinical perspectives on overcoming these barriers to advance personalized cancer treatment. The eBook brings together expert insights, peer-reviewed research, and practical applications to provide a complete overview of the current state and future directions of adoptive cell therapy for solid tumors.

Expert interview

In an interview, Dr. Leonardo Ferreira, Assistant Professor of Pharmacology and Immunology at the Medical University of South Carolina, discusses the physical and biological barriers that limit the success of adoptive cell therapies in the treatment of solid tumors. He also discusses the role of tumor-infiltrating lymphocytes in reshaping immune responses and recent innovations improving immune cell infiltration. Dr. Ferreira also addresses the challenges and opportunities of allogeneic cell therapies and identifies promising biomarkers for guiding therapy selection and monitoring.

Research highlights

The eBook features two peer-reviewed articles that highlight recent advances in the development of adoptive cell therapies for solid malignancies. The first article examines the key obstacles that limit the efficacy of CAR-T cells in solid tumors and discusses strategies to overcome these limitations. The second article explores the role of tumor-associated macrophages in the tumor microenvironment. It also outlines how macrophages can be reprogrammed or targeted to enhance anti-tumor immune responses, offering complementary strategies to T-cell-based therapies for more comprehensive cancer treatment approaches.

Additional resources 

The eBook includes additional perspectives on the evolving landscape of adoptive cell therapy:

• News article: It highlights emerging research on leveraging CD4 T cells for enhanced anti-tumor responses.
• Application note: It provides practical guidance on the isolation of tumor-associated macrophages from fresh tumor tissue.
• White paper: It examines the critical role of HLA typing in developing safe and effective personalized cell therapies, addressing compatibility challenges and immune rejection risks.

This eBook was made in collaboration with RegMedNet