PromoCell: driving scientific advances across research areas

High-impact findings across research areas

Over 13% of peer-reviewed publications using our products appeared in prestigious journals with impact factors (IF) exceeding 10.0. These high-impact journals include Nature (IF: 49.96), Cell (IF: 41.58), Nature Medicine (IF: 53.44), and Immunity (IF: 31.74). The extensive use of our products in high-impact publications underscores our crucial role in enabling groundbreaking research that shapes our understanding of human biology and disease.

The reach of our products spans multiple research disciplines and showcases our commitment to advancing life science research and innovation. Let’s explore how our products are advancing research across different fields.

Dermatology research

Recent research using our Normal Human Epidermal Keratinocytes (NHEK) has shed light on the mechanisms underlying skin disorders and paved the way for the development of new treatments for chronic inflammatory skin conditions such as psoriasis. A recent study published in Nature Communications investigated the role of hepcidin in the pathogenesis of psoriasis.¹ This discovery builds on five decades of observations linking elevated iron levels to psoriatic conditions.

Using in vitro 3D human skin cultures and mouse models, researchers uncovered the crucial role of hepcidin, a hormone that regulates iron levels, in initiating skin inflammation. By using our NHEK to develop in vitro skin models, researchers were able to demonstrate how modulating hepcidin activity could potentially manage chronic inflammation in patients with psoriasis. This finding is particularly significant as it establishes hepcidin as a key regulator of both iron levels and inflammation and provides a novel target for drug development in psoriasis and other chronic skin conditions.

Cardiovascular research

Our human primary cardiac myocytes have helped researchers to develop innovative approaches for treating cardiac diseases. Using our Human Primary Cardiac Myocytes (HCM), scientists at Tokyo Medical University recently demonstrated the potential of adult -derived extracellular vesicles (EVs) in the treatment of cardiac fibrosis. Published in the Journal of Extracellular Vesicles, their research showed that these EVs could reduce fibroblast activation and improve cardiac function in vivo.²

The researchers also found that adult cardiomyocyte-derived EVs contained microRNAs targeting antifibrotic pathways and that the cardiac microenvironment enhances EV uptake by cardiac fibroblasts. This study represents a significant step forward in developing cell-free therapies for cardiac conditions, potentially offering less invasive treatment options for patients with heart disease.

Angiogenesis and vascular research

Angiogenesis, the formation of new blood vessels, is an area of research with implications for cancer, cardiovascular diseases, and neurodegeneration. Researchers have used our products to study angiogenesis and related diseases. Researchers at Copenhagen University Hospital developed a triple co-culture system using our Endothelial Cell Growth Medium 2 to study the pro-angiogenic potential of adipose-derived mesenchymal stromal cells (AD-MSCs).³ The researchers also developed a functional model combining fibroblasts, HUVECs, and AD-MSCs. Their work, published in Stem Cell Research, demonstrates AD-MSCs as promising candidates for treating ischemic diseases.³

In another collaborative study published in JCI Insight, researchers in Barcelona and Munich used our Primary Human Umbilical Vein Endothelial Cells (HUVECs) and Endothelial Cell Growth Medium to investigate the role of TDP-43 in angiogenesis and vascular stability. The researchers found that TDP-43, a DNA/RNA-binding protein, regulated sprouting angiogenesis and vascular barrier integrity.⁴ Their findings have important implications for understanding neurodegenerative disorders with vascular abnormalities.

Cancer research

Our products are helping researchers uncover new therapeutic targets in oncology. A recent Nature Communications study on osteosarcoma used our Human Osteoblasts and bone marrow-derived Human Mesenchymal Stem Cells (hMSC) to investigate the role of RNA-binding proteins in bone cancer development. The study showed that RNA interactomes in osteosarcoma cells mirror those of mesenchymal stem cells, opening new possibilities for RNA-targeted therapies.⁵ In addition, the researchers identified the IGF2BP3-Myc feedback loop as a promising therapeutic target for this bone malignancy that primarily affects young people.

Aging and metabolic research

Our products are also advancing our understanding of aging and metabolism. In a collaborative study published in Genome Medicine, researchers at UCLA and the University of Helsinki used our Preadipocyte Differentiation Medium and Adipocyte Nutrition Medium to support their research into the relationship between aging and obesity, focusing on adipose stem and progenitor cells (ASPCs).⁶ By integrating bulk and single-nucleus RNA sequencing data, researchers found that obesity prematurely reduces the proportion of ASPCs, linking aging to obesity.

The researchers also identified 76 age-affected genes that are deregulated in ASPCs during aging, shedding light on the cellular and genetic interactions connecting aging to obesity.

Quality and reproducibility

We are committed to advancing human-centered science through consistent product quality, innovation in cell culture solutions, and technical support. From basic research to translational studies and technological innovations, our high-quality products provide the reliability and reproducibility essential for innovative research.

Our commitment to excellence is evidenced by the inclusion of our products in prestigious protocol publications, including Nature Protocols, Cell Reports Methods, Small Methods, and STAR Protocols. This recognition underscores the reliability and reproducibility of the results achieved with our products, making them the preferred choice for researchers developing and disseminating new methods available for the scientific community to advance life science research.

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