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Air-liquid interface culture: getting a closer look into our airways
Air-liquid interface culture (ALI) allow scientists to generate stable and functional in vitro 3D human airway cell models that closely mimic respiratory tract epithelia. With such models, researchers can investigate physiological and pathological processes of the respiratory tract. They can study interactions between epithelial cells and respiratory pathogens or air pollutants,… -
Exploring the glycolytic and TCA pathways
Respiratory pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, and the mitochondrial electron transport chain are essential for cellular energy and various physiological functions throughout nature. Glycolysis is a crucial biological mechanism, allowing cells to gain access to the energy they need. This means the enzymes of the glycolytic pathway are potential targets in cancer therapy and diabetes…. -
Finding new targets for diabetes drug development using in vitro cell assays
Diabetes is a global healthcare problem with a growing prevalence. The disease is systemic, leading to reduced quality of life if untreated. A myriad of assays and research tools are available to study the disease and find effective treatments…. -
Studying oxidative stress and skin aging using in vitro human cell culture models
Oxidative stress results from an imbalance of pro- and anti-oxidants and leads to faster skin aging, inflammation and disease. Cell assays and primary cells provide the tools researchers need to study the oxidative process and its association with skin aging…. -
Infographic: What are theadvantages of primary cells over cell Lines in respiratory research?
Cell lines have been used for decades in respiratory research, but concerns over accurate lineage identification and other issues mean researchers are turning to primary cells – which offer a host of other benefits too. Read our infographic to learn why primary cells are great tools for respiratory research. ​​… -
HLA class II typed cells to accelerate effective research on immunotherapies
We support effective research on immunotherapies by expanding the range of HLA-types provided for all Human Primary Cells and Blood & Stem Cells. In addition to the MHC class I genes HLA-A, -B, and -C, we now also offer 4-digit resolution for MHC class II genes HLA-DPA1/DPB1, -DQA1/DQB1, and -DRB1/DRB345. The Human Leukocyte Antigen (HLA) system plays a fundamental role in the determination of histocompatibility between different individuals and regulation of the human immunity….