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Search results for: 'blog in vitro obesity research'

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  • Custom cell culture media solutions

    Our custom cell culture media solutions include products that are tailored to your needs. We own our entire manufacturing process, so we can create customized products for clients in a huge range of markets worldwide. We empower scientists to conduct world-class research by offering an extensive portfolio of human primary cells,… Go To Page

  • Cell expansion service

    Our custom cell expansion service can be of great help in your research. Depending on the requirements of the field of your research (e.g., RNA-seq, high-throughput screening for drug discovery, toxicity screening for immunotherapy development), large numbers of primary cells are inevitable. Upscaling your cell culture in-house can be challenging for many reasons…. Go To Page

  • Download your GMP relevant documentation

    If your search does not return any results, please contact us for assistance…. Go To Page

  • Immuno-oncology

    A new in vitro strategy Immuno-oncology is a unique combination of oncology and immunology. By activating or amplifying the body’s natural defenses, immuno-oncology aims to boost the immune system to fight cancer better. Targeted antibodies or immunomodulators are well-known immunotherapies; adoptive cell therapy using CAR-T or TCR cells is particularly important,… Go To Page

  • CSC therapy – towards new opportunities

    CSCs as therapeutic targets Cancer stem cells (CSCs) are a small subset of tumor cells that are able to evade anti-tumor defense mechanisms and suppress anti-tumor immune responses by releasing soluble immunosuppressive factors, such as anti-inflammatory cytokines. CSCs appear to have multiple strategies to escape immunological destruction, including the acquisition of genetic and non-genetic alterations that reduce immune recognition,… Go To Page

  • Tumor microenvironment

    The role of CSCs and the TME Cellular interactions in the tumor microenvironment (TME) significantly influence cancer progression and drug response. The efficacy of immunotherapies has triggered increased interest in the tumor immune microenvironment. Therefore, robust experimental systems are needed to enable researchers to model patient-specific interactions between tumor cells and immune cells…. Go To Page

  • Extracellular vesicles in cancer therapy

    EVs in tumor development Extracellular vesicles (EVs), including exosomes, play a crucial role in tumor biology. Alongside modulating the tumor microenvironment and contributing to the malignant cascade (angiogenesis, the host immune system response, and metastasis), EVs are involved in chemoresistance. Docetaxel in prostate cancer, for example, may transport mRNA encoding drug-resistant proteins or carry miRNA to recipient cells and trigger the expression of specific target genes…. Go To Page

  • Applications for our cancer media toolbox

    We have developed a toolbox of cancer cell media to establish primary cancer cell lines from biopsies, develop 3D tumor models or build screening assays. Below you find the different application areas to discover solutions for your workflow and choose the right medium or combination of media to leverage your cancer research…. Go To Page

  • From biopsy to assay development

    Struggling to get high quality biopsies? Isolating patient-derived cancer cells from different types of biopsies (bone marrow biopsy, core needle biopsy, endoscopic biopsy, etc.) is the golden standard for cancer research. However, obtaining regular surgical biopsies from patients is a challenging prospect. Additionally, the variability of the quality of tissue samples can be pretty high…. Go To Page

  • Cancer stem cell selection

    Advance cancer stem cell culture Cancer stem cells (CSCs) are a specific and small subpopulation of tumor cells. Despite their low number, they drive tumor initiation, influence tumor progression, and cause metastasis and relapse. Increased cancer stem cell populations have been shown to reflect the aggressiveness and therapy-resistant phenotype of the tumor…. Go To Page

  • Making best use of your PDX mouse

    Transfer from PDX to in vitro assays Xenograft models are extensively used to provide information about the safety and efficacy in drug development, especially for targeted cancer therapies. Patient-derived xenograft (PDX) mice are the preferred mouse tumor models, but cell line-derived xenografts (CDXs) and nude rat xenografts are also used. Nevertheless,… Go To Page

  • 3D cancer model

    De-skilling 3D tumor models Tissue-engineered 3D cancer models have grown in popularity with recent advances in cancer research. 3D models are more biomimetic than 2D cell monolayers cultured on tissue culture plastic. Examples are spheroids, tumorspheres, organoids, PDX and lately, tumoroids, which differ by origin (cell line or patient-derived), size, the complexity of cellular architecture and tumor environment…. Go To Page

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