Videos
Items 13-18 of 18 Results
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Cells in Action: membrane protrusions in HUVECs (Human Umbilical Vein Endothelial Cells)
During angiogenesis, cell-matrix interactions are crucial. The cell matrix structures are involved in migration, invasion and survival of cells throughout the angiogenic process. In this video we can see filopodia and lamellipodia in great detail, thanks to Nanolive imaging's ability to view membrane deformations. These structures are essential for migration, cell-cell interactions, sensing of the cell environment and more. While filopodia appear as long, thin protrusion-like structures that emerge from the cellular membrane, lamellipodia are broad, sheet-shaped structures containing thin and short interconnected actin filaments.
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Cells in Action: Double mitosis of Human Umbilical Vein Endothelial Cells (HUVECs)
Images of cells undergoing mitosis are mind-blowing, and non more beautiful than those of our Human Umbilical Vein Endothelial Cells (HUVECs) captured by Nanolive's 3D Cell Explorer. On the right hand side, the cell seems to enter mitosis but the chromatids don't complete segregation and the cell returns to interphase without dividing. Exiting mitosis is controlled by proteolysis and cyclin dependent kinases (CDKs). Mitosis regulatory machinery sometimes detects errors and forces a return to interphase, as seen here. This kind of research helps develop understanding of the cell cycle, which can be used in myriad applications including cancer research.
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Cancer cell culture: Diversity of cells in the tumor microenvironment (TME)
Tumor growth is sustained by a highly diverse microenvironment, the TME. Its complex cellular interactions need serious consideration during Cancer Research.
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Macrophages Subtypes: Polarization, Activation and Plasticity
Macrophages are multitasking cells at the first line of defense against pathogens invasion. But they can also play a major role in destroying tissues and developing cancer, autoimmune disorder or allergies.
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Advancing immuno-oncology: Innovative solutions for adoptive cell therapy
Advances in immuno-oncology continue to transform cancer treatment, offering hope where traditional therapies have fallen short.
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From clumps to consistency: Advancing reproducible 3D cancer models
Reliable 3D cancer models are essential—but conventional tumorsphere workflows can still produce inconsistent, heterogeneous clumps. In this webinar, we'll introduce a streamlined, matrix free workflow built around our 3D Tumorsphere Medium XF. This approach enables the generation of uniform, robust tumorspheres across multiple cancer types – without additional tools or extracellular matrices. We'll share data showing improved tumorsphere formation efficiency and long term expansion of patient derived tumor cells while preserving key tumor characteristics. We’ll then explore how these robust spheroids can be integrated into the MIVO® cancer on chip platform, from React4Life, to move from static cultures to dynamic, physiologically relevant systems. By recreating key biophysical cues of the tumor microenvironment, this approach supports more predictive studies of tumor behavior and drug response. What you'll learn: How to generate uniform, reproducible tumorspheres using a matrix free workflow Strategies to support cancer stem cell–driven growth across cancer types How to integrate 3D spheroids into dynamic cancer on chip systems How fluid flow and shear stress improve modeling of tumor invasion and drug efficacy
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