Proper protection of your personal data is a serious matter for PromoCell GmbH and we conform strictly to all data protection laws and regulations. The following declaration provides an overview of how we ensure this protection, as well as which types of data are collected and to what purpose. Scope of application This privacy statement informs users of the types,…
Go To Page
Cancer stem cell selection
Advance cancer stem cell culture Cancer stem cells (CSCs) are a specific and small subpopulation of tumor cells. Despite their low number, they drive tumor initiation, influence tumor progression, and cause metastasis and relapse. Increased cancer stem cell populations have been shown to reflect the aggressiveness and therapy-resistant phenotype of the tumor….
Go To Page
EV cancer treatment cell media: Importance and challenges
Since the birth of extracellular vesicle (EV) cancer treatment, EVs have provided invaluable biomarkers for cancer diagnosis and stable drug vehicles for treatment delivery. Correct isolation and suitable cell culture growth media are indispensable in producing effective, non-toxic EV cancer treatments….
Go To Page
Cancer stem cells in tumor biology
How do cancer stem cells develop? What is their role in tumor biology? What are current approaches to target cancer stem cells? And what are innovative solutions for working with them? Find all the answers in our blog post….
Go To Page
CSC therapy – towards new opportunities
CSCs as therapeutic targets Cancer stem cells (CSCs) are a small subset of tumor cells that are able to evade anti-tumor defense mechanisms and suppress anti-tumor immune responses by releasing soluble immunosuppressive factors, such as anti-inflammatory cytokines. CSCs appear to have multiple strategies to escape immunological destruction, including the acquisition of genetic and non-genetic alterations that reduce immune recognition,…
Go To Page
Tumor microenvironment
The role of CSCs and the TME Cellular interactions in the tumor microenvironment (TME) significantly influence cancer progression and drug response. The efficacy of immunotherapies has triggered increased interest in the tumor immune microenvironment. Therefore, robust experimental systems are needed to enable researchers to model patient-specific interactions between tumor cells and immune cells….
Go To Page
Making best use of your PDX mouse
Transfer from PDX to in vitro assays Xenograft models are extensively used to provide information about the safety and efficacy in drug development, especially for targeted cancer therapies. Patient-derived xenograft (PDX) mice are the preferred mouse tumor models, but cell line-derived xenografts (CDXs) and nude rat xenografts are also used. Nevertheless,…
Go To Page
Holotomography: 3D Non-Invasive Live-Cell Imaging of Stem Cells
Real-time tracking of stem cells during cell culture experiments can provide fundamental new insights into their biology. Yet stem cells are very sensitive to experiment-induced stress, and the use of labeling agents or intense light can damage them. With holotomography technology, long-term 3D live-cell imaging of stem cells under physiological conditions is possible – without the use of exogenous dyes and with no phototoxicity….
Go To Page
3D cancer model
De-skilling 3D tumor models Tissue-engineered 3D cancer models have grown in popularity with recent advances in cancer research. 3D models are more biomimetic than 2D cell monolayers cultured on tissue culture plastic. Examples are spheroids, tumorspheres, organoids, PDX and lately, tumoroids, which differ by origin (cell line or patient-derived), size, the complexity of cellular architecture and tumor environment….
Go To Page
From biopsy to assay development
Struggling to get high quality biopsies? Isolating patient-derived cancer cells from different types of biopsies (bone marrow biopsy, core needle biopsy, endoscopic biopsy, etc.) is the golden standard for cancer research. However, obtaining regular surgical biopsies from patients is a challenging prospect. Additionally, the variability of the quality of tissue samples can be pretty high….
Go To Page
Where and how our products have been used – discover the new bioz widget
With the bioz search widget it’s now even easier to find out where our products have been used in a context that’s relevant to you….
Go To Page
EXCiPACT™ GMP certified produced cell culture media
A crucial step when developing new drugs and cell therapies and during development of new cosmetics or cell-based food production, is the translation of a technology from the research laboratory to clinical use in the real world, and subsequently commercial manufacturing. To ensure this step goes well, understanding and evaluating potential raw material risks of media and reagents is key when working with products in a regulated environment….
Go To Page