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Search results for: 'making best use of your pdx mouse'

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  • Making best use of your PDX mouse

    Transfer from PDX to in vitro assays Xenograft models are extensively used to provide information about the safety and efficacy in drug development, especially for targeted cancer therapies. Patient-derived xenograft (PDX) mice are the preferred mouse tumor models, but cell line-derived xenografts (CDXs) and nude rat xenografts are also used. Nevertheless,… Go To Page

  • PDX mouse: Pushing the possibilities with ex vivo cell culture

    Innovating mouse research such as PDX mouse models is key to improving cancer therapeutics. In translating scientific findings from mice to men, multiple techniques of collecting biological data are necessary. This article will explain how…. Go To Page

  • 3D cancer model

    De-skilling 3D tumor models Tissue-engineered 3D cancer models have grown in popularity with recent advances in cancer research. 3D models are more biomimetic than 2D cell monolayers cultured on tissue culture plastic. Examples are spheroids, tumorspheres, organoids, PDX and lately, tumoroids, which differ by origin (cell line or patient-derived), size, the complexity of cellular architecture and tumor environment…. Go To Page

  • Primary Cancer Cells: A Culture System Opens the Door to Individualized Therapy

    Self-destruction of the body: Cancer turns normal body cells into their malignant counterpart that wants to keep on replicating by any means. Understanding the individual disease offers the potential for more effective therapies with fewer side effects. The new PromoCell Primary Cancer Culture System allows researchers to generate high-fidelity in vitro models of primary tumors…. Go To Page

  • Holotomography: 3D Non-Invasive Live-Cell Imaging of Stem Cells

    Real-time tracking of stem cells during cell culture experiments can provide fundamental new insights into their biology. Yet stem cells are very sensitive to experiment-induced stress, and the use of labeling agents or intense light can damage them. With holotomography technology, long-term 3D live-cell imaging of stem cells under physiological conditions is possible – without the use of exogenous dyes and with no phototoxicity…. Go To Page

  • Scaling up from 2D monolayers to complex 3D cell cultures

    Using three-dimensional cell cultures is more popular today than ever. Yet as the complexity of cell culture increases – from 2D cell culture, spheroids, 3D models up to organoids – so do the variables. This means you should plan carefully before advancing from 2D to 3D cell culture. Keeping several key factors in mind,… Go To Page

  • Top tips for incorporating organoids into your research: expert interview

    Our expert, Dr. Elfie Rödel, shares her top tips for incorporating organoids into your research in an interview with RegMedNet…. Go To Page

  • Introducing a novel high throughput 3D wound healing model

    Non-healing wounds continue to cause significant patient burden. This blog details a novel 3D wound healing model that promises to facilitate the development of new treatments to promote wound healing.  … Go To Page

  • Starting with 3D cell culture

    Making use of 3D cell culture can give you access to new and powerful in vitro models that model the in vivo environment. In this overview, you’ll be introduced to the main methods in 3D culture and how best to use them in your research…. Go To Page

  • In the spotlight – PromoExQ MSC Growth Medium XF nominated for Scientists’ Choice Awards 2024

    You can cast your vote now…. Go To Page

  • Meet Zinnia (Naoshin) Noor, Scientific Application Manager (International Distribution Sales)

    Read out our latest employee profile about Dr Zinnia Noor, our scientific application manager…. Go To Page

  • HLA class II typed cells to accelerate effective research on immunotherapies

    We support effective research on immunotherapies by expanding the range of HLA-types provided for all Human Primary Cells and Blood & Stem Cells. In addition to the MHC class I genes HLA-A, -B, and -C, we now also offer 4-digit resolution for MHC class II genes HLA-DPA1/DPB1, -DQA1/DQB1, and -DRB1/DRB345. The Human Leukocyte Antigen (HLA) system plays a fundamental role in the determination of histocompatibility between different individuals and regulation of the human immunity…. Go To Page

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