Macrophage plasticity is more than black and white
Many rules in biology exist, and even more exceptions to these rules. For years, immunologists have tried to classify macrophages into two subtypes, classically activated M1, and alternatively activated M2 macrophages. However, with the growing number of activated macrophage subtypes needing description, established nomenclature falls short. Researchers are seeking an alternative to the traditional black-and-white principle….
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Macrophages Subtypes: Polarization, Activation and Plasticity
Macrophages are multitasking cells at the first line of defense against pathogens invasion. But they can also play a major role in destroying tissues and developing cancer, autoimmune disorder or allergies….
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Top tips for incorporating organoids into your research: expert interview
Our expert, Dr. Elfie Rödel, shares her top tips for incorporating organoids into your research in an interview with RegMedNet….
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Macrophages: The high-flyers of biomedical research
One cell type can fight disease, help form blood vessels, regulate cell stability— and more. Macrophages are true masters of multitasking. In our body they are the first line of defense against invading bacteria, fungi and viruses. But they are not only a key element of our immune defense; they can also play a role in destroying tissue,…
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HLA-Typed Primary Cells: The advantages of working with HLA in drug development research
For those working in drug development, human leukocyte antigens or HLA are a key element to keep in mind as an essential regulator of the immune system….
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Thawing frozen cells – detailed protocol for human primary cells
Thawing cells correctly is absolutely necessary when it comes to successfully starting reliable cell cultures. Find out how to thaw frozen primary cells properly in our detailed video protocol….
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The immunomodulatory properties of mesenchymal stem cells (MSCs)
Since their discovery in 1991, mesenchymal stem cells, or MSCs, have been used as a promising method to build tissue. However, MSCs can do more for the development of cell and gene therapies. Find out more in our video….
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Five Steps to Writing a Great Scientific Article
Thousands of scientific articles are published each year. It’s a basic series of steps in biomedical research: do experiments, analyze data, publish your results, and repeat. It seems straightforward, but one question remains. How do you write a paper for publication if it’s your first one?
A blank white page, and a silently blinking cursor: How can an empty document be so intimidating?…
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Adipocytes: key players in metabolic homeostasis
Adipocytes do more than simply store fat. They also play a role in metabolic diseases. Through better understanding of how adipose cells function and interact, researchers can develop new, targeted therapies for treating adipositas and diabetes.
Our bodies and the bodies of all living organisms work like batteries: we get energy from food,…
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Cells in action: Differentiation of human mesenchymal stem cells into neurons
In this video we can see the differentiation of PromoCell umbilical cord mesenchymal stem cells into neurons. Excitingly, to our knowledge this is one of the first high-resolution, long-term, live cell time-lapses showing this process. These cells were grown for 13 days in PromoCell complete mesenchymal stem cell neurogenic differentiation medium prior to capture of this film….
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Cells in Action: membrane protrusions in HUVECs (Human Umbilical Vein Endothelial Cells)
During angiogenesis, cell-matrix interactions are crucial. The cell matrix structures are involved in migration, invasion and survival of cells throughout the angiogenic process. In this video we can see filopodia and lamellipodia in great detail, thanks to Nanolive imaging’s ability to view membrane deformations. These structures are essential for migration, cell-cell interactions,…
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Malignant mesothelioma: Paving the way for new therapies
From bench to bedside and back: This is the direction of malignant mesothelioma research. Yet to understand the biology of this particular type of cancer, more basic insights are still needed. And translating that knowledge into new therapies is extremely important, as only limited therapeutic options exist so far.
Molecular needles that cross the lung epithelium: That’s how asbestos – often in form of dust – enters lung tissue (Carbone et al.,…
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