Malignant mesothelioma: Paving the way for new therapies
From bench to bedside and back: This is the direction of malignant mesothelioma research. Yet to understand the biology of this particular type of cancer, more basic insights are still needed. And translating that knowledge into new therapies is extremely important, as only limited therapeutic options exist so far.
Molecular needles that cross the lung epithelium: That’s how asbestos – often in form of dust – enters lung tissue (Carbone et al.,…
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Advancements and applications of tumor organoids in cancer research
Organoid models of patient-specific tumors are transforming our understanding of cancer heterogeneity and its implications for personalized medicine.
In this interview with BioTechniques, our experts, Janina Moros, Alexander Trampe and Zinnia Noor, discuss the benefits of tumor organoids, how to establish and culture them and their applications across different areas of cancer biology….
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Immuno-oncology
A new in vitro strategy Immuno-oncology is a unique combination of oncology and immunology. By activating or amplifying the body’s natural defenses, immuno-oncology aims to boost the immune system to fight cancer better. Targeted antibodies or immunomodulators are well-known immunotherapies; adoptive cell therapy using CAR-T or TCR cells is particularly important,…
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A young scientist seeks a method to knock out fibrosis
Lab work is exciting, says Bastian Fischer. Even experiments that just yield their expected results inspire the young German scientist. Fischer is currently working on his PhD, and is investigating how fibrosis develops, so that effective therapies for this medical condition can be found.
A scar is often all that remains of a deep cut – if anything remains at all….
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Teaching the body to fight tumors using cancer immunotherapy
Selected as the 2013 “Breakthrough of the Year” by Science magazine, cancer immunotherapy shows a completely new way to treat malignancies by using the body’s own immune system, and not by targeting the tumor itself. This cutting-edge area of research and therapy has shown very promising results. However, further investigation is needed to turn immunotherapy into a cancer therapy that can be broadly applied….
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Cancer stem cells in tumor biology
How do cancer stem cells develop? What is their role in tumor biology? What are current approaches to target cancer stem cells? And what are innovative solutions for working with them? Find all the answers in our blog post….
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Histocompatibility: Piecing together the immunotherapy puzzle
What do puzzles and immunity have in common? The human leukocyte antigen (HLA) system of cell-surface proteins help to regulate the immune system. Yet particular antigens can make a crucial difference. Patients with certain HLA types are more likely to have autoimmune diseases, contract infectious disease or develop cancer. Now, through better understanding of HLA function,…
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15 cell culture facts: Things about cell culture you might not know
As a researcher working in cell culture, you must have a deep understanding of your specific research area. However, scientific knowledge is advancing rapidly. Therefore, keeping up with all the developments in cell-based research can be challenging. In this article, we present 15 facts about cell culture that can add to your knowledge….
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Branching out: In vitro angiogenesis advancements
In this interview with RegMedNet, our expert, Iris Bischoff-Kont, discusses the latest advancements in angiogenesis research and their potential applications in regenerative medicine. Dr Bischoff-Kont also explores the challenges faced in translating angiogenesis research findings into clinical therapies and the importance of understanding the crosstalk between angiogenesis and other processes like inflammation….
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Primary Cancer Cells: A Culture System Opens the Door to Individualized Therapy
Self-destruction of the body: Cancer turns normal body cells into their malignant counterpart that wants to keep on replicating by any means. Understanding the individual disease offers the potential for more effective therapies with fewer side effects. The new PromoCell Primary Cancer Culture System allows researchers to generate high-fidelity in vitro models of primary tumors….
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Cancer stem cell selection
Advance cancer stem cell culture Cancer stem cells (CSCs) are a specific and small subpopulation of tumor cells. Despite their low number, they drive tumor initiation, influence tumor progression, and cause metastasis and relapse. Increased cancer stem cell populations have been shown to reflect the aggressiveness and therapy-resistant phenotype of the tumor….
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Cancer Stem Cells
Definition of Cancer Stem Cells Cancer stem cells (CSCs) are rare, immortal cells within a tumor that display the characteristics of stemness. Stemness means that a cell has the ability to perpetuate its lineage, give rise to differentiated cells, as well as to interact with its environment to maintain a balance between quiescence,…
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