Why do HDMEC cultures sometimes show two different cell morphologies?

PromoCell Human Dermal Microvascular Endothelial Cells (HDMEC) are isolated from the dermis of juvenile foreskin or adult skin.
The dermis contains both blood capillaries and lymphatic capillaries. As a result, HDMEC cultures typically comprise a mixture of blood microvascular endothelial cells and lymphatic microvascular endothelial cells, which may display distinct morphologies in culture.
Both cell populations are of endothelial origin and can be identified using established endothelial and lymphatic markers.
Please note: The proportion of blood and lymphatic endothelial cells may vary from lot to lot and is not routinely determined by PromoCell.
 
For applications requiring a more homogeneous endothelial cell population, PromoCell also offers:

• Human Dermal Blood Endothelial Cells (HDBEC; C‑12211, C‑12225)
• Human Dermal Lymphatic Endothelial Cells (HDLEC; C‑12216, C‑12217)

These cell types are derived from HDMEC cultures and subsequently enriched for either blood endothelial cells or lymphatic endothelial cells, respectively.
Our Scientific Support team will be happy to assist you in selecting the most suitable endothelial cell type for your application.