Human Uterine Microvascular Endothelial Cells (HUtMEC)
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Primary Human Uterine Microvascular Endothelial Cells (HUtMEC) are isolated from the myometrium (middle layer of the uterine wall) from single donors who are not pre-treated with hormones. The cells stain positive for CD31 and von Willebrand factor and negative for smooth muscle α-actin.
During pregnancy HUtMEC propagate intensely and change their phenotype and expression pattern in response to sex steroids. This includes up-regulation of HUtMEC nitric oxide synthase activity, modulation of adhesion molecule expression, and an increase in endothelial cell survival and angiogenic activity. HUtMEC are involved in medical conditions like uterine fibroma or adenomysis.
- Request our GMP grade cell culture media for endothelial cells.
- Our HUtMEC are now also available from HLA-typed donors.
| Recommended plating density | 10,000 - 20,000 cells per cm2 |
| Passage after thawing | P2 |
| Tested markers | CD31 positive, Dil-Ac-LDL uptake positive |
| Guaranteed population doubling | > 15 |
| Recommended culture media* | C-22020, C-22022 |
*The catalog numbers in this table are for media in ready-to-use packaging.
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