Why is the serum content of PromoCell's specialized media so low?

FCS is a natural product consisting of many different components like salts hormones vitamins trace elements proteins and enzymes. There can be large lot-to-lot variations between different serum batches regarding the concentrations of growth-promoting factors. The higher the serum content in a culture medium the higher the impact of the variations on the cell culture system. For this reason PromoCell has developed several serum-reduced and serum-free media where part of the serum has been replaced by more defined factors like cytokines hormones or vitamins.Media with reduced serum concentrations have the benefit that they produce more standardized culture conditions over a long time span.