HLA-Typed Primary Cells: The advantages of working with HLA in drug development research
For those working in drug development, human leukocyte antigens or HLA are a key element to keep in mind as an essential regulator of the immune system….
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Histocompatibility: Piecing together the immunotherapy puzzle
What do puzzles and immunity have in common? The human leukocyte antigen (HLA) system of cell-surface proteins help to regulate the immune system. Yet particular antigens can make a crucial difference. Patients with certain HLA types are more likely to have autoimmune diseases, contract infectious disease or develop cancer. Now, through better understanding of HLA function,…
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For faster research on immunotherapies: HLA-typed human primary cells
– HLA-typed human primary cells for researchers across the world
– Great tool in the development and testing of new cancer drugs
– HLA-typed donor characteristics are precisely documented…
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HLA class II typed cells to accelerate effective research on immunotherapies
We support effective research on immunotherapies by expanding the range of HLA-types provided for all Human Primary Cells and Blood & Stem Cells. In addition to the MHC class I genes HLA-A, -B, and -C, we now also offer 4-digit resolution for MHC class II genes HLA-DPA1/DPB1, -DQA1/DQB1, and -DRB1/DRB345.
The Human Leukocyte Antigen (HLA) system plays a fundamental role in the determination of histocompatibility between different individuals and regulation of the human immunity….
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Could HLA-type be the answer to individual differences in COVID-19 severity?
The COVID-19 pandemic has changed the world. While vaccines are now being approved, a true understanding of the biological processes underlying COVID-19 and why some individuals develop severe disease while others are asymptomatic is necessary. HLA-type could be a key differentiator in disease outcomes, and in developing treatments….
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Air-liquid interface culture: getting a closer look into our airways
Air-liquid interface culture (ALI) allow scientists to generate stable and functional in vitro 3D human airway cell models that closely mimic respiratory tract epithelia. With such models, researchers can investigate physiological and pathological processes of the respiratory tract. They can study interactions between epithelial cells and respiratory pathogens or air pollutants,…
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Immuno-oncology
A new in vitro strategy Immuno-oncology is a unique combination of oncology and immunology. By activating or amplifying the body’s natural defenses, immuno-oncology aims to boost the immune system to fight cancer better. Targeted antibodies or immunomodulators are well-known immunotherapies; adoptive cell therapy using CAR-T or TCR cells is particularly important,…
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The immunomodulatory properties of mesenchymal stem cells (MSCs)
Since their discovery in 1991, mesenchymal stem cells, or MSCs, have been used as a promising method to build tissue. However, MSCs can do more for the development of cell and gene therapies. Find out more in our video….
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Thawing frozen cells – detailed protocol for human primary cells
Thawing cells correctly is absolutely necessary when it comes to successfully starting reliable cell cultures. Find out how to thaw frozen primary cells properly in our detailed video protocol….
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The importance of HLA for the development of cell therapies
Thanks to a greater understanding of human leukocyte antigen (HLA) function, researchers can now work toward developing new cancer immunotherapies….
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Five Steps to Writing a Great Scientific Article
Thousands of scientific articles are published each year. It’s a basic series of steps in biomedical research: do experiments, analyze data, publish your results, and repeat. It seems straightforward, but one question remains. How do you write a paper for publication if it’s your first one?
A blank white page, and a silently blinking cursor: How can an empty document be so intimidating?…
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Discover our Air-Liquid Interface (ALI) culture system
Our standardized Air-Liquid Interface (ALI) Medium in combination with ALI pre-screened Human Bronchial Epithelial Cells enables creation of a reproducible human 3D airway model with stable and predictable epithelial barrier function….
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