Switching products can be easy – if you do it right
If you’re looking to switch to new reliable media or human primary cells and don’t know where to start – look no further. We’ve got you covered….
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Optimizing cryopreservation: Serum-free cell freezing medium
Cryopreservation is an integral part of biomedical research and clinical applications. However, maintaining cell viability and function during freezing and thawing can be challenging. Serum-free cryopreservation media formulations are advanced solutions that can be used instead of serum-containing freezing media to maintain cell function while ensuring reproducibility and standardization — read on to learn why….
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Mesenchymal stem cells: why optimizing manufacturing processes is key for a successful application
Mesenchymal stem cells (MSCs) are the up-and-coming stars of cell therapy. They are able to differentiate, are very adaptable and can reduce inflammation, making them ideal for regenerative medicine approaches. But the demand for MSCs is far greater than supply. Pharmaceutical companies are racing to produce commercial-scale quantities of MSCs while guaranteeing quality standards….
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Why you should know your human mesenchymal stem cells inside out
Doctors, and patients with chronic diseases, are putting hope into new findings in regenerative medicine that are based on mesenchymal stem cell (MSC) research. As promising as some published results sound, they might be not reproducible – simply due to insufficient authentication and poor handling of cell cultures. Rigorous validation of cell identity is crucial for working with human mesenchymal stem cells – and,…
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Macrophage plasticity is more than black and white
Many rules in biology exist, and even more exceptions to these rules. For years, immunologists have tried to classify macrophages into two subtypes, classically activated M1, and alternatively activated M2 macrophages. However, with the growing number of activated macrophage subtypes needing description, established nomenclature falls short. Researchers are seeking an alternative to the traditional black-and-white principle….
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Using 3D Skin Models to Test Cosmetics
Skin is the primary focus of cosmetic research. Since the European Union banned animal testing of cosmetics completely in 2013, three-dimensional skin models have been used to evaluate epidermal and dermal responses to cosmetic formulations. Such models provide a reliable tool to assess the functionality and safety of new cosmetic products….
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Macrophages: The high-flyers of biomedical research
One cell type can fight disease, help form blood vessels, regulate cell stability— and more. Macrophages are true masters of multitasking. In our body they are the first line of defense against invading bacteria, fungi and viruses. But they are not only a key element of our immune defense; they can also play a role in destroying tissue,…
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Cancer Stem Cells
Definition of Cancer Stem Cells Cancer stem cells (CSCs) are rare, immortal cells within a tumor that display the characteristics of stemness. Stemness means that a cell has the ability to perpetuate its lineage, give rise to differentiated cells, as well as to interact with its environment to maintain a balance between quiescence,…
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The right choice of endothelial cells for your vascular research
Human umbilical vein cells (HUVECs) are easy to access, so they have been the major source of primary endothelial cells (ECs) for years. But to study adult vascular pathology, bring your endothelial research to the next level – by choosing adult ECs that more accurately resemble in vitro conditions….
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Air-liquid interface culture: getting a closer look into our airways
Air-liquid interface culture (ALI) allow scientists to generate stable and functional in vitro 3D human airway cell models that closely mimic respiratory tract epithelia. With such models, researchers can investigate physiological and pathological processes of the respiratory tract. They can study interactions between epithelial cells and respiratory pathogens or air pollutants,…
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3D skin model: The promise for dermatology
The development of 3D skin models has revolutionized in vitro studies in dermatology, offering a more representative platform for understanding skin structure and function in health and disease. In this article, we explain the biology of the human skin and explore the transformative potential of 3D skin models in reshaping our understanding of skin function….
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Endothelial to mesenchymal transition: Beyond blood vessels
Endothelial to mesenchymal transition (EndMT) is a complex biological process that is essential for various physiological functions, from embryonic development to tissue repair.1 But what happens when the mechanisms underlying EndMT are deregulated? In this article, we explore the intricacies of EndMT, discussing its mechanisms, role in health and disease, and therapeutic potential….
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