Macrophages: The high-flyers of biomedical research
One cell type can fight disease, help form blood vessels, regulate cell stability— and more. Macrophages are true masters of multitasking. In our body they are the first line of defense against invading bacteria, fungi and viruses. But they are not only a key element of our immune defense; they can also play a role in destroying tissue,…
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Discover our wide range of human blood cells
Are you developing cell and gene therapies or working in the field of immunology or immuno-oncology and are looking for high quality human blood cells? Discover more information on our range on our human blood cells flyer….
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Mesenchymal Stem Cells: Challenges and chances in cancer therapy
As the potential for using mesenchymal stem cells in cancer therapy grows, understanding the biology behind them can help inform and inspire innovative cancer therapies. Using high quality media and culture kits will increase the efficiency and usability of these highly demanded cells.
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Cells in action: Differentiation of human mesenchymal stem cells into neurons
In this video we can see the differentiation of PromoCell umbilical cord mesenchymal stem cells into neurons. Excitingly, to our knowledge this is one of the first high-resolution, long-term, live cell time-lapses showing this process. These cells were grown for 13 days in PromoCell complete mesenchymal stem cell neurogenic differentiation medium prior to capture of this film….
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Cells in Action: Human Primary Keratinocytes at the stratum granulosum
Keratinocytes at the stratum granulosum contain two characteristic structures that are visible in this high resolution footage by Nanolive – the lamellar bodies and keratohyalin granules. While keratohyalin granules contain proteins involved in the aggregation of keratin filaments and in the formation of the cell envelope, lamellar bodies contain lipids and fuse with the plasma membrane in order to secrete the content into the extracellular space….
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Tumor microenvironment
The role of CSCs and the TME Cellular interactions in the tumor microenvironment (TME) significantly influence cancer progression and drug response. The efficacy of immunotherapies has triggered increased interest in the tumor immune microenvironment. Therefore, robust experimental systems are needed to enable researchers to model patient-specific interactions between tumor cells and immune cells….
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PromoCell now exclusive supplier of MATra (Magnet-Assisted Transfection)
Primary cells can prove much more difficult to transfect than other commonly used cell lines. While high transfection efficiencies are possible using commercially available transfection reagents in diverse, commonly used cell lines, primary cells but also diverse cell lines have proven much more difficult to transfect….
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Macrophage plasticity is more than black and white
Many rules in biology exist, and even more exceptions to these rules. For years, immunologists have tried to classify macrophages into two subtypes, classically activated M1, and alternatively activated M2 macrophages. However, with the growing number of activated macrophage subtypes needing description, established nomenclature falls short. Researchers are seeking an alternative to the traditional black-and-white principle….
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Histocompatibility: Piecing together the immunotherapy puzzle
What do puzzles and immunity have in common? The human leukocyte antigen (HLA) system of cell-surface proteins help to regulate the immune system. Yet particular antigens can make a crucial difference. Patients with certain HLA types are more likely to have autoimmune diseases, contract infectious disease or develop cancer. Now, through better understanding of HLA function,…
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Cells in Action: Double mitosis of Human Umbilical Vein Endothelial Cells (HUVECs)
Images of cells undergoing mitosis are mind-blowing, and non more beautiful than those of our Human Umbilical Vein Endothelial Cells (HUVECs) captured by Nanolive’s 3D Cell Explorer.
On the right hand side, the cell seems to enter mitosis but the chromatids don’t complete segregation and the cell returns to interphase without dividing….
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Branching out: In vitro angiogenesis advancements
In this interview with RegMedNet, our expert, Iris Bischoff-Kont, discusses the latest advancements in angiogenesis research and their potential applications in regenerative medicine. Dr Bischoff-Kont also explores the challenges faced in translating angiogenesis research findings into clinical therapies and the importance of understanding the crosstalk between angiogenesis and other processes like inflammation….
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Top tips for incorporating organoids into your research: expert interview
Our expert, Dr. Elfie Rödel, shares her top tips for incorporating organoids into your research in an interview with RegMedNet….
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