Stem cell therapy scientist: Finding inspiration outside his comfort zone
Crossing the border between medical and biomechanical research fuels the research of stem cell specialist Dr. Diego Correa. We talked to the Colombian-born stem cell scientist, a former clinician with training in mechanical engineering, about his studies with mesenchymal stem cells and their potential clinical applications in cell-based therapy. Soon Correa is going to publish what he believes will be his most important contribution to this field….
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A young scientist seeks a method to knock out fibrosis
Lab work is exciting, says Bastian Fischer. Even experiments that just yield their expected results inspire the young German scientist. Fischer is currently working on his PhD, and is investigating how fibrosis develops, so that effective therapies for this medical condition can be found.
A scar is often all that remains of a deep cut – if anything remains at all….
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Mesenchymal Stem Cells: Challenges and chances in cancer therapy
As the potential for using mesenchymal stem cells in cancer therapy grows, understanding the biology behind them can help inform and inspire innovative cancer therapies. Using high quality media and culture kits will increase the efficiency and usability of these highly demanded cells.
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Cancer stem cells in tumor biology
How do cancer stem cells develop? What is their role in tumor biology? What are current approaches to target cancer stem cells? And what are innovative solutions for working with them? Find all the answers in our blog post….
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Five Steps to Writing a Great Scientific Article
Thousands of scientific articles are published each year. It’s a basic series of steps in biomedical research: do experiments, analyze data, publish your results, and repeat. It seems straightforward, but one question remains. How do you write a paper for publication if it’s your first one?
A blank white page, and a silently blinking cursor: How can an empty document be so intimidating?…
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Trouble With Your Primary Cells? Treat Them Nicely!
What seems basic to cell culturing is pure stress for primary cells: thawing, subcultivation and freezing. Even seasoned scientists tend to overlook this aspect, and manipulate their cultures less carefully than they should. Unhealthy, or even dead cells are the sad consequence. Here, you can benefit from an expert’s tips in handling primary cells,…
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Why you should know your human mesenchymal stem cells inside out
Doctors, and patients with chronic diseases, are putting hope into new findings in regenerative medicine that are based on mesenchymal stem cell (MSC) research. As promising as some published results sound, they might be not reproducible – simply due to insufficient authentication and poor handling of cell cultures. Rigorous validation of cell identity is crucial for working with human mesenchymal stem cells – and,…
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Endothelial Cells
Definition Endothelial cells form the barrier between vessels and tissues (Aman et al., 2016). They control the flow of substances and fluid into and out of a tissue. An impaired function can lead to serious health issues throughout the body. Endothelial cells line blood vessels and lymphatic vessels, they are found exclusively in vascularized tissue (Bautch and Caron,…
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Histocompatibility: Piecing together the immunotherapy puzzle
What do puzzles and immunity have in common? The human leukocyte antigen (HLA) system of cell-surface proteins help to regulate the immune system. Yet particular antigens can make a crucial difference. Patients with certain HLA types are more likely to have autoimmune diseases, contract infectious disease or develop cancer. Now, through better understanding of HLA function,…
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Rocket science: The mystery of how macrophages adapt in space
In recent decades, many in vitro studies with living human cells have broadened our knowledge about the cellular and molecular effects of microgravity. Cells of the immune system are particularly sensitive to it and represent an ideal model for understanding how space flight could affect cell function. Prof. Ullrich and his team have greatly contributed to explaining how cells behave in space….
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Malignant mesothelioma: Paving the way for new therapies
From bench to bedside and back: This is the direction of malignant mesothelioma research. Yet to understand the biology of this particular type of cancer, more basic insights are still needed. And translating that knowledge into new therapies is extremely important, as only limited therapeutic options exist so far.
Molecular needles that cross the lung epithelium: That’s how asbestos – often in form of dust – enters lung tissue (Carbone et al.,…
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15 cell culture facts: Things about cell culture you might not know
As a researcher working in cell culture, you must have a deep understanding of your specific research area. However, scientific knowledge is advancing rapidly. Therefore, keeping up with all the developments in cell-based research can be challenging. In this article, we present 15 facts about cell culture that can add to your knowledge….
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