Cells in Action: Double mitosis of Human Umbilical Vein Endothelial Cells (HUVECs)
Images of cells undergoing mitosis are mind-blowing, and non more beautiful than those of our Human Umbilical Vein Endothelial Cells (HUVECs) captured by Nanolive’s 3D Cell Explorer.
On the right hand side, the cell seems to enter mitosis but the chromatids don’t complete segregation and the cell returns to interphase without dividing….
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Cells in Action: membrane protrusions in HUVECs (Human Umbilical Vein Endothelial Cells)
During angiogenesis, cell-matrix interactions are crucial. The cell matrix structures are involved in migration, invasion and survival of cells throughout the angiogenic process. In this video we can see filopodia and lamellipodia in great detail, thanks to Nanolive imaging’s ability to view membrane deformations. These structures are essential for migration, cell-cell interactions,…
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The right choice of endothelial cells for your vascular research
Human umbilical vein cells (HUVECs) are easy to access, so they have been the major source of primary endothelial cells (ECs) for years. But to study adult vascular pathology, bring your endothelial research to the next level – by choosing adult ECs that more accurately resemble in vitro conditions….
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Endothelial to mesenchymal transition: Beyond blood vessels
Endothelial to mesenchymal transition (EndMT) is a complex biological process that is essential for various physiological functions, from embryonic development to tissue repair.1 But what happens when the mechanisms underlying EndMT are deregulated? In this article, we explore the intricacies of EndMT, discussing its mechanisms, role in health and disease, and therapeutic potential….
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Branching out: In vitro angiogenesis advancements
In this interview with RegMedNet, our expert, Iris Bischoff-Kont, discusses the latest advancements in angiogenesis research and their potential applications in regenerative medicine. Dr Bischoff-Kont also explores the challenges faced in translating angiogenesis research findings into clinical therapies and the importance of understanding the crosstalk between angiogenesis and other processes like inflammation….
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Endothelial Cells
Definition Endothelial cells form the barrier between vessels and tissues (Aman et al., 2016). They control the flow of substances and fluid into and out of a tissue. An impaired function can lead to serious health issues throughout the body. Endothelial cells line blood vessels and lymphatic vessels, they are found exclusively in vascularized tissue (Bautch and Caron,…
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In vitro angiogenesis: Advancing biomedical research
Scientists have used in vitro angiogenesis as a model to further our understanding of the formation of blood vessels and the potential for therapeutic interventions. Curious to learn how? Read on to learn about the role of innovative in vitro models in unraveling the mechanisms regulating angiogenesis in a controlled laboratory setting….
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From disease to healing: Exploring the roles of pericytes
They are multipotent, interact closely with endothelial cells, and are involved in immunosurveillance: the heterogeneous group of pericytes. These cells build the wall of blood vessels, and play a crucial role in the formation and maintenance of the vasculature. Due to their involvement in various pathophysiologies such as tumor angiogenesis, scientists are beginning to exploit their potential for therapeutic approaches….
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How Oxygen Affects Primary Cell Culture
Oxygen has two faces: While it’s a life-saving gas essential for humans and animals, excessive generation of reactive oxygen species damages cells and promotes senescence. This duality is the research focus of Professor Giovanni E. Mann of King’s College London. Prof. Mann and his colleagues are currently investigating redox signaling in vascular cells in culture….
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Engineering a beating heart: The promise of cardiac spheroids
Innovative cardiac models are key to understanding heart diseases and finding new, potentially life-saving therapies. Bioprinting cardiac spheroids using primary human cells is a significant step toward creating a human beating heart in vitro. This article will explain why….
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Understanding the vasculature with the help of HUVECs
Cells that feed other cells: The endothelium is a layer of cells that line blood vessels, and it is responsible for many tasks, including the transport of essential nutrients. Human umbilical vein endothelial cells (HUVECs) provide an in-vitro model for studying physiological and pathological processes of the vasculature.
“I’ll never forget the first time I added cancer cells to a HUVECs monolayer and watched them interact….
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Mimicking the body’s largest organ in vitro with 3D skin models
Researchers are increasingly using 3D cell cultures to study the skin’s features. Three-dimensional skin models offer the potential to study various diseases and test compounds in vitro. Dr. Florian Groeber-Becker from the Fraunhofer Institute for Silicate Research ISC in Wurzburg has developed a highly sophisticated skin model.
It is the first thing people see when they look at us….
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