Respiratory pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, and the mitochondrial electron transport chain are essential for cellular energy and various physiological functions throughout nature. Glycolysis is a crucial biological mechanism, allowing cells to gain access to the energy they need. This means the enzymes of the glycolytic pathway are potential targets in cancer therapy and diabetes….
Go To Page
Cancer stem cells in tumor biology
How do cancer stem cells develop? What is their role in tumor biology? What are current approaches to target cancer stem cells? And what are innovative solutions for working with them? Find all the answers in our blog post….
Go To Page
Branching out: In vitro angiogenesis advancements
In this interview with RegMedNet, our expert, Iris Bischoff-Kont, discusses the latest advancements in angiogenesis research and their potential applications in regenerative medicine. Dr Bischoff-Kont also explores the challenges faced in translating angiogenesis research findings into clinical therapies and the importance of understanding the crosstalk between angiogenesis and other processes like inflammation….
Go To Page
Endothelial to mesenchymal transition: Beyond blood vessels
Endothelial to mesenchymal transition (EndMT) is a complex biological process that is essential for various physiological functions, from embryonic development to tissue repair.1 But what happens when the mechanisms underlying EndMT are deregulated? In this article, we explore the intricacies of EndMT, discussing its mechanisms, role in health and disease, and therapeutic potential….
Go To Page
Holotomography: 3D Non-Invasive Live-Cell Imaging of Stem Cells
Real-time tracking of stem cells during cell culture experiments can provide fundamental new insights into their biology. Yet stem cells are very sensitive to experiment-induced stress, and the use of labeling agents or intense light can damage them. With holotomography technology, long-term 3D live-cell imaging of stem cells under physiological conditions is possible – without the use of exogenous dyes and with no phototoxicity….
Go To Page
PromoCells in space continues – producing human tissue in a weightless environment
Two research leaders from the University of Zurich (UZH) Space Hub, Professor Oliver Ullrich and Dr. Cora Thiel, have sent adult human stem cells to the International Space Station (ISS). They are testing an innovative method to produce human tissue in a weightless environment, and hope to better understand how human tissue is produced in the weightless atmosphere of space….
Go To Page
Endothelial Cells
Definition Endothelial cells form the barrier between vessels and tissues (Aman et al., 2016). They control the flow of substances and fluid into and out of a tissue. An impaired function can lead to serious health issues throughout the body. Endothelial cells line blood vessels and lymphatic vessels, they are found exclusively in vascularized tissue (Bautch and Caron,…
Go To Page
Top tips for incorporating organoids into your research: expert interview
Our expert, Dr. Elfie Rödel, shares her top tips for incorporating organoids into your research in an interview with RegMedNet….
Go To Page
Advancements and applications of tumor organoids in cancer research
Organoid models of patient-specific tumors are transforming our understanding of cancer heterogeneity and its implications for personalized medicine.
In this interview with BioTechniques, our experts, Janina Moros, Alexander Trampe and Zinnia Noor, discuss the benefits of tumor organoids, how to establish and culture them and their applications across different areas of cancer biology….
Go To Page
PDX mouse: Pushing the possibilities with ex vivo cell culture
Innovating mouse research such as PDX mouse models is key to improving cancer therapeutics. In translating scientific findings from mice to men, multiple techniques of collecting biological data are necessary. This article will explain how….
Go To Page
EV cancer treatment cell media: Importance and challenges
Since the birth of extracellular vesicle (EV) cancer treatment, EVs have provided invaluable biomarkers for cancer diagnosis and stable drug vehicles for treatment delivery. Correct isolation and suitable cell culture growth media are indispensable in producing effective, non-toxic EV cancer treatments….
Go To Page