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Search results for: 'news starting with 3d cell culture'

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  • Starting with 3D cell culture

    Making use of 3D cell culture can give you access to new and powerful in vitro models that model the in vivo environment. In this overview, you’ll be introduced to the main methods in 3D culture and how best to use them in your research…. Go To Page

  • 3D cancer model

    De-skilling 3D tumor models Tissue-engineered 3D cancer models have grown in popularity with recent advances in cancer research. 3D models are more biomimetic than 2D cell monolayers cultured on tissue culture plastic. Examples are spheroids, tumorspheres, organoids, PDX and lately, tumoroids, which differ by origin (cell line or patient-derived), size, the complexity of cellular architecture and tumor environment…. Go To Page

  • Cancer stem cell selection

    Advance cancer stem cell culture Cancer stem cells (CSCs) are a specific and small subpopulation of tumor cells. Despite their low number, they drive tumor initiation, influence tumor progression, and cause metastasis and relapse. Increased cancer stem cell populations have been shown to reflect the aggressiveness and therapy-resistant phenotype of the tumor…. Go To Page

  • Invisible attraction: Using magnets to develop drugs in cell cultures

    Modern medicines are high-tech products. Developing medicines increasingly includes high throughput screening by fully automated analysis robots. One exciting high throughput approach uses magnetic 3D cell culture – which provides a more realistic model of human tissue than with 2D cell culture. The later a candidate drops out, the more expensive it is…. Go To Page

  • Using 3D Skin Models to Test Cosmetics

    Skin is the primary focus of cosmetic research. Since the European Union banned animal testing of cosmetics completely in 2013, three-dimensional skin models have been used to evaluate epidermal and dermal responses to cosmetic formulations. Such models provide a reliable tool to assess the functionality and safety of new cosmetic products…. Go To Page

  • A Home for Cancer Stem Cells: 3D Tumorspheres

    Many scientists working in oncology focus on cancer stem cells (CSCs). Targeting these cells specifically could improve cancer therapy significantly. Because CSCs rely heavily on their environment, three-dimensional cultivation offers the unique opportunity to better understand this interaction. We talked to two scientists working in this field of cancer research. In the human body,… Go To Page

  • Top tips for incorporating organoids into your research: expert interview

    Our expert, Dr. Elfie Rödel, shares her top tips for incorporating organoids into your research in an interview with RegMedNet…. Go To Page

  • Making best use of your PDX mouse

    Transfer from PDX to in vitro assays Xenograft models are extensively used to provide information about the safety and efficacy in drug development, especially for targeted cancer therapies. Patient-derived xenograft (PDX) mice are the preferred mouse tumor models, but cell line-derived xenografts (CDXs) and nude rat xenografts are also used. Nevertheless,… Go To Page

  • Create a 3D human airway model with air-liquid interface culture

    Generation of a 3D human airway model with primary human nasal and tracheal epithelial cells using our Air-Liquid Interface Medium (ALI-Airway)…. Go To Page

  • Malignant mesothelioma: Paving the way for new therapies

    From bench to bedside and back: This is the direction of malignant mesothelioma research. Yet to understand the biology of this particular type of cancer, more basic insights are still needed. And translating that knowledge into new therapies is extremely important, as only limited therapeutic options exist so far. Molecular needles that cross the lung epithelium: That’s how asbestos – often in form of dust – enters lung tissue (Carbone et al.,… Go To Page

  • From biopsy to assay development

    Struggling to get high quality biopsies? Isolating patient-derived cancer cells from different types of biopsies (bone marrow biopsy, core needle biopsy, endoscopic biopsy, etc.) is the golden standard for cancer research. However, obtaining regular surgical biopsies from patients is a challenging prospect. Additionally, the variability of the quality of tissue samples can be pretty high…. Go To Page

  • Cancer stem cells in tumor biology

    How do cancer stem cells develop? What is their role in tumor biology? What are current approaches to target cancer stem cells? And what are innovative solutions for working with them? Find all the answers in our blog post…. Go To Page

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