Finding new targets for diabetes drug development using in vitro cell assays
Diabetes is a global healthcare problem with a growing prevalence. The disease is systemic, leading to reduced quality of life if untreated. A myriad of assays and research tools are available to study the disease and find effective treatments….
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In vitro angiogenesis: Advancing biomedical research
Scientists have used in vitro angiogenesis as a model to further our understanding of the formation of blood vessels and the potential for therapeutic interventions. Curious to learn how? Read on to learn about the role of innovative in vitro models in unraveling the mechanisms regulating angiogenesis in a controlled laboratory setting….
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PDX mouse: Pushing the possibilities with ex vivo cell culture
Innovating mouse research such as PDX mouse models is key to improving cancer therapeutics. In translating scientific findings from mice to men, multiple techniques of collecting biological data are necessary. This article will explain how….
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Cells that could lead to new therapies: PromoCell now offers in vitro disease models
– Portfolio extension: Wide range of donor cells with common chronic diseases
– New models can help researchers investigate disease development and find new treatment approaches
– Matched growth media are optimized for pharmaceutical drug discovery…
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Cancer stem cells in tumor biology
How do cancer stem cells develop? What is their role in tumor biology? What are current approaches to target cancer stem cells? And what are innovative solutions for working with them? Find all the answers in our blog post….
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Immuno-oncology
A new in vitro strategy Immuno-oncology is a unique combination of oncology and immunology. By activating or amplifying the body’s natural defenses, immuno-oncology aims to boost the immune system to fight cancer better. Targeted antibodies or immunomodulators are well-known immunotherapies; adoptive cell therapy using CAR-T or TCR cells is particularly important,…
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Tumor microenvironment
The role of CSCs and the TME Cellular interactions in the tumor microenvironment (TME) significantly influence cancer progression and drug response. The efficacy of immunotherapies has triggered increased interest in the tumor immune microenvironment. Therefore, robust experimental systems are needed to enable researchers to model patient-specific interactions between tumor cells and immune cells….
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Endothelial Cells
Definition Endothelial cells form the barrier between vessels and tissues (Aman et al., 2016). They control the flow of substances and fluid into and out of a tissue. An impaired function can lead to serious health issues throughout the body. Endothelial cells line blood vessels and lymphatic vessels, they are found exclusively in vascularized tissue (Bautch and Caron,…
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Branching out: In vitro angiogenesis advancements
In this interview with RegMedNet, our expert, Iris Bischoff-Kont, discusses the latest advancements in angiogenesis research and their potential applications in regenerative medicine. Dr Bischoff-Kont also explores the challenges faced in translating angiogenesis research findings into clinical therapies and the importance of understanding the crosstalk between angiogenesis and other processes like inflammation….
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Invisible attraction: Using magnets to develop drugs in cell cultures
Modern medicines are high-tech products. Developing medicines increasingly includes high throughput screening by fully automated analysis robots. One exciting high throughput approach uses magnetic 3D cell culture – which provides a more realistic model of human tissue than with 2D cell culture.
The later a candidate drops out, the more expensive it is….
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Adipocytes: key players in metabolic homeostasis
Adipocytes do more than simply store fat. They also play a role in metabolic diseases. Through better understanding of how adipose cells function and interact, researchers can develop new, targeted therapies for treating adipositas and diabetes.
Our bodies and the bodies of all living organisms work like batteries: we get energy from food,…
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CSC therapy – towards new opportunities
CSCs as therapeutic targets Cancer stem cells (CSCs) are a small subset of tumor cells that are able to evade anti-tumor defense mechanisms and suppress anti-tumor immune responses by releasing soluble immunosuppressive factors, such as anti-inflammatory cytokines. CSCs appear to have multiple strategies to escape immunological destruction, including the acquisition of genetic and non-genetic alterations that reduce immune recognition,…
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