Cosmetics & Dermatology Since the total ban of animal experiments by strict EU regulations, scientists in the cosmetic industry have been relying on cultured primary cells in 2-D or 3-D. Our comprehensive portfolio for dermatological portfolio not only offers scientists to work comfortably with 2-D or 3-D cell cultures but also allows to generate organoids or perform co-culture experiments with different cell types from matched donors. Overview The skin is the largest and most versatile organ in the human body, providing an effective barrier between organism and environment. The complex architecture involves three layers: the epidermis made up of keratinocytes, Merkel cells, melanocytes and Langerhans cells in an interconnected network. The dermis containing hair follicles, sweat glands, sebaceous glands, apocrine glands, lymphatic vessels, blood vessels and protein fibers. Finally, the subcutis with adipocytes, fibroblasts, macrophages, and connective tissue binding the skin to underlying layers of muscle and bone. From reacting to sensory stimuli to regulating body temperature and storing lipids and water, the skin performs a plethora of functions to maintain physiological function. With this complex structure comes the potential for complex pathophysiology – the skin must heal wounds and prevent infection to maintain health. Advances in dermatological research provide insights into the skin-organ, aiming to improve treatment of skin damage from disease, wounds or burns. Cell culture assays give us the basic knowledge that could translate into new therapies for disease. We have a complete portfolio for dermatological research, with key dermatological cell types from matched donors, making co-culture experiments with different cell types possible. Our comprehensive portfolio of dermatological cells can be used for both 2D and 3D cell culture.Availability of different cell types from matched donors enables co-culture experiments. Along with a wide selection of donors, we have specific information available on donor characteristics and tissue localization (e.g. face, breast, etc.). Research shows that HLA molecules play a major role in regulating immune responses. This is pertinent to dermatological research where susceptibilities to several skin diseases are linked to different HLA classes (e.g. Vitiligo, psoriasis). To enable dermatological research, we offer cells from donors who are typed for HLA.
