SARS-CoV-2/ACE Binding Inhibitor Screening Kit

Rapid, simple and sensitive colorimetric assay to screen for potential inhibitors of SARS-Cov S1 protein binding to human ACE2.

SARS-CoV-2/ACE Binding Inhibitor Screening Kit
PK-CA577-K2050
  100 assays
$ 799.00

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SARS-CoV-2/ACE Binding Inhibitor Screening Kit

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The Spike protein S1 subunit of the SARS-CoV-2 outer envelope contains a receptor-binding domain that can specifically bind to the host-receptor namely Angiotensin Converting Enzyme 2 (ACE2), which facilitates the entry of the virus into the target cells including respiratory or intestinal epithelial cells, endothelial cells, alveolar monocytes or macrophages. The receptor recognition step is an important determinant of the viral infectivity, pathogenesis & host range. Therefore, an intervention strategy that targets S1 protein and ACE2 interaction presents an important target for vaccination or antiviral strategies that includes small molecules and therapeutic antibodies.