HDAC Inhibitor Screening Kits

Rapid, simple, sensitive, and reliable fluorometric assay which is suitable for high throughput screening of HDAC3 inhibitors.

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Selected product HDAC Inhibitor Screening Kits

HDAC-5 Inhibitor Screening Kit 100 assays

HDAC-6 Inhibitor Screening Kit 100 assays

HDAC-3 Inhibitor Screening Kit 100 assays

HDAC-8 Inhibitor Screening Kit 100 assays

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Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major event that controls eukaryotic gene transcription and are classified into three groups. They are believed to be involved in important biological activities, such as cell proliferation & differentiation, cell motility, cell cycle, transcriptional & epigenetic regulation, apoptosis, senescence, and oxidative stress. HDACs also play a role in several diseases patterns and are therefore attractive targets for e.g. anticancer or Alzheimer therapy.

PromoCell’s HDAC Inhibitor Screening Kits are platebased fluorometric assays for screening/studying/characterizing potential HDAC inhibitors. They are based on the deacetylation of an acetylated specific peptide substrate by the respective HDAC. This deacetylated product is then cleaved by a developer to release a highly fluorescent moiety which can be easily quantified using a conventional microplate reader. In the presence of an HDAC-selective inhibitor, the deacetylase activity of HDAC6 is reduced/abolished resulting in decrease or total loss of the fluorescence.

The kits also include wellknown inhibitor controls for the respective HDAC enzyme. Individual HDAC Inhibitors can be found on our website. In addition, we also provide a range of HDAC antibodies & peptides.

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