AKR1C3 Inhibitor I

A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 that also showed potency in a cellular assay, blocking the ability of AKR1C3 to metabolize a proven substrate.

Please be aware that this product will be discontinued and will only be available until: 21.12.2021

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AKR1C3 Inhibitor I 5 mg

AKR1C3 Inhibitor I 25 mg

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A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. In repeat assays it showed an IC₅₀ of 0.013 ± 0.003 μM for AKR1C3, compared with 20.3 ± 3.8 μM against AKR1C1 and >30 μM against AKR1C2 and AKR1C4. This inhibitor also showed potency in a cellular assay, blocking the ability of AKR1C3 to metabolize a proven substrate. Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.