AGI-6780

A potent, selective inhibitor of mutant Isocitrate dehydrogenase 2 (IDH2).

Please be aware that this product will be discontinued and will only be available until: 21.12.2021

Choose Variant
×

Selected product AGI-6780

AGI-6780 5 mg

AGI-6780 25 mg

Add to cart to purchase or to request a quote

This product is not currently available.

AGI-6780 is a potent, selective inhibitor of mutant Isocitrate dehydrogenase 2 (IDH2) (IC₅₀ = 23 nM). It binds allosterically at the dimer interface of mutant IDH2-R140Q, inhibiting 2-hydroxyglutarate (2-HG) formation in human glioblastoma U87 and TF-1 cells expressing IDH2-R140Q with IC₅₀ values of 11 and 18 nM, respectively.