AG-881

A potent and selective inhibitor of mutated forms of both isocitrate dehydrogenase type 1.

Please be aware that this product will be discontinued and will only be available until: 21.12.2021

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AG-881 1 mg

AG-881 5 mg

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AG-881 (Vorasidenib) is a potent and selective inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP⁺], mitochondrial) in the mitochondria, with potential antineoplastic activity. AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG).