AG-221 (Enasidenib)

A potent IDH2 (Isocitrate dehydrogenase 2) inhibitor.

Please be aware that this product will be discontinued and will only be available until: 21.12.2021

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AG-221 (Enasidenib) 5 mg

AG-221 (Enasidenib) 25 mg

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AG-221 (Enasidenib) is a potent, selective, and reversible inhibitor of mutant IDH2 (isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduces 2-HG levels by >90%, reverses histone and DNA hypermethylation, and induces cellular differentiation in leukemia cell models.