AAK1 (AP2-associated protein kinase 1) is a serine/threonine kinase that is thought to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the µ2 subunit. There is strong evidence that this protein is the endogenous mu 2 kinase and plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.
|Host Subclass||Rabbit IgG|
|Immunogen||Synthetic peptide surrounding amino acid 850 of human AAK1.|
|Reactive Species||Human, Mouse, Rat|
|Formulation||100 µg (0.50 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.50% BSA, and 0.01% thimerosal.|
|Reconstitution||Can be diluted in other aqueous buffers at the concentrations determined for the respective application.|
|Stability & Storage||Store at -20°C. For long-term storage, aliquot and refreeze at -70°C. Avoid repeated freeze/thaw cycles.|