2′-Deoxy-5-fluorocytidine

A DNA methyltransferase (DNMT) inhibitor that acts as a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP (FdUMP).

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Selected product 2'-Deoxy-5-fluorocytidine

2′-Deoxy-5-fluorocytidine 50 mg

2′-Deoxy-5-fluorocytidine 250 mg

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A DNA methyltransferase (DNMT) inhibitor. Acts as a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP (FdUMP) and is a potential drug for treatment of breast cancer and other solid tumors. 2′-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation. It blocks proliferation of colon cancer-derived HCT-116 cells by activating DNA response pathways and inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.