1400W (dihydrochloride)

A slow, tight binding and highly selective, cell-permeable inhibitor of iNOS.

Choose Variant

Selected product 1400W (dihydrochloride)

1400W (dihydrochloride) 5 mg

1400W (dihydrochloride) 25 mg

Add to cart to purchase or to request a quote

Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤ 7 nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Kᵢ values of 2 and 50 µM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.