α-Naphthoflavone

A potent inhibitor of Cytochrome P450 enzymes (Aromatase, 1A2, 1A1, 1B1).

Please be aware that this product will be discontinued and will only be available until: 21.12.2021

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α-Naphthoflavone 25 g

α-Naphthoflavone 5 g

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α-Naphthoflavone modulates xenobiotic metabolism by antagonizing the aryl hydrocarbon receptor (AhR), blocking the expression of phase I and II genes at nanomolar concentrations. It can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50 = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.