Different physiological and environmental factors such as chemically induced
damage and cell aging cause DNA lesions. AP sites (apurinic/apyrimidinic
sites) are one of the major types of DNA lesions formed during the process
of base excision and repair of oxidized, deaminated, or alkylated bases. It has
been estimated that about 200,000 base lesions are generated per cell per day.
For this reason, the level of AP sites in cells can be a good indicator of DNA lesions and repairs.
Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids (e.g. membrane lipids) containing carbon-carbon double bonds. The chemical products of this oxidation are known as lipid peroxides. Lipid peroxidation alters the physical properties of cellular membranes and can cause covalent modification of proteins and nucleic acids.
PromoCell offers a range of sensitive, easy-to-use assays to study DNA damage as well as lipid peroxidation.
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