Liver Metabolism & Clearance Assays

The liver is the main site of metabolism clearance. Most drugs are cleared there by CYP proteins that cause Phase I biotransformation reactions. The most common mechanism underlying drug-drug interactions is the inhibition of cytochrome P450 activities. Of the family of CYP proteins, CYP1, CYP2, CYP3 and CYP4 are the most important in terms of drug biotranformations.

PromoCell’s Cytochrome P450 (CYP) & Monoamine Oxidase (MAO) Activity Assay Kits permit rapid, convenient and sensitive fluorometric measurement of native or recombinant CYP/MAO activity in biological samples such as liver microsomes and tissue or hepatic cells with a high signal-to-background ratio and little interference from autofluorescence.

Our Cytochrome P450 (CYP) & MAO-A/MAO-B Inhibitor Screening Kits permit rapid screening of drugs (e.g. MAO-A & MAO-B inhibitors) and other new chemical entities (NCEs) for compound-CYP interaction in a reliable, high-throughput assay.

No products were found matching your selection.