Glutamine/Glutamate Metabolism

PromoCell supplies a range of user-friendly, sensitive and high-throughput-compatible assays to study the glutamine/glutamate metabolism as well as screening compounds that regulate/inhibit specific enzymes of that pathway and might be new drug candidates to treat diseases such as cancer, diabetes or neurological disorders.

In addition, we also offer a variety of biochemicals such as inhibitors and activators that can be used with the respective assays as well as antibodies and other useful products for cellular analysis.

Glutamine is the most abundant amino acid in blood and muscles and is largely utilized for energy generation and as a precursor for new biomolecules.
It is known that cancer cells can reprogram glucose metabolism for aerobic glycolysis using glutamine as an additional energy source and building block for increasing proliferation. Glutamine is converted to glutamate, which is involved in the energy-producing TCA cycle but is also critical for maintaining redox homeostasis and protecting cells from oxidative stress by producing glutathione (GSH).