COVID-19 is caused by a novel Coronavirus (CoV) called SARS-CoV-2, also known as 2019-nCoV. The disease outbreak was first discovered in Wuhan, China but has spread to many other countries with up-to-date millions of laboratory-confirmed infections and several hundred thousand of fatal cases. The World Health Organization (WHO) has declared a global health emergency to gather resources and remedy this threat.
Background
There are four coronavirus genera: alpha-coronavirus, beta-coronavirus, gamma-coronavirus, and delta-coronavirus. SARS-CoV-2 belongs to the beta-coronavirus genus originating from bats. Beta-coronaviruses can infect mammals, are zoonotic pathogens, and can cause severe respiratory disease in humans.
Other viruses in this family are SARS coronavirus (SARS-CoV) and MERS coronavirus. SARS-CoV-2 has approximately 79% sequence identity to SARS-CoV and 50% to MERS-CoV which gives us clues as to how it may infect and cause disease in humans. In addition, homology modeling shows SARS-CoV-2 has a similar receptor-binding domain structure as SARS-CoV which suggests SARS-CoV-2 uses the angiotensin-converting enzyme-2 (ACE2) receptor in humans for infection. A significant amount of research has already been done to understand ACE2 and how it may be used as a host receptor by viruses, giving us a head-start when fighting COVID-19.
The ACE2 SARS-CoV-2 Interaction
ACE2 is expressed in the human heart, lung, kidney and gastrointestinal tract and is an essential regulator of heart function and blood pressure. ACE2 is a functional receptor, acting as the entry point into human lung cells for both SARS-CoV and the human respiratory coronavirus (HCoV-NL63). This makes it a potential target for therapy that could prevent COVID-19 infection.
Research into the interaction between SARS-CoV-2 and ACE2 is key as this dynamic is crucial to understanding both cross-species and human to human transmissions of COVID-19.
Tools to Study COVID-19
To support the efforts of researchers worldwide to study, understand and combat this new health threat, PromoCell offers a range of high-quality antibodies specifically directed against components of the SARS-CoV-2 and the ACE2 receptor.
As ACE2 is a potential therapeutic target not only for cardiovascular disorders but also for coronavirus-induced diseases, we also provide an ACE2 Activity Assay as well as an ACE Inhibitor Screening Assay to further support research progress in this field.
Please note: All products are for research use only and not for in vitro-diagnostic or therapeutic purposes.
Product list
Assays
| PK-CA577-K897 | ACE2 Activity Assay Kit | Fast, and simple fluorometric detection of Angiotensin II Converting Enzyme activity in tissue/cell lysates. | 100 assays |
| PK-CA577-K310 | ACE2 Inhibitor Screening Kit | Simple fluorometric assay that can be used to identify and characterize Angiotensin II Converting Enzyme inhibitors/activators in a high-throughput format. | 100 assays |
| PK-CA577-K2050 | SARS-CoV-2/ACE Binding Inhibitor Screening Kit | Rapid, simple and sensitive colorimetric assay to screen for potential inhibitors of SARS-Cov S1 protein binding to human ACE2. | 100 assays |
SARS Antibodies & Blocking Peptides
| PK-AB718-3219 | SARS Spike (NT) antibody (pAb) | Rabbit Anti-SARS Virus Membrane Protein | 100 µg |
| PK-AB718-3219P | SARS Spike (NT) peptide | Viral SARS Spike (NT) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3221 | SARS Spike (IN1) antibody (pAb) | Rabbit Anti-SARS Virus Membrane Protein | 100 µg |
| PK-AB718-3221P | SARS Spike (IN1) peptide | Viral SARS Spike (IN1) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3223 | SARS Spike (IN2) antibody (pAb) | Rabbit Anti-SARS Virus Membrane Protein | 100 µg |
| PK-AB718-3223P | SARS Spike (IN2) peptide | Viral SARS Spike (IN2) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3225 | SARS Spike (IN3) antibody (pAb) | Rabbit Anti-SARS Virus Membrane Protein | 100 µg |
| PK-AB718-3225P | SARS Spike (IN3) peptide | Viral SARS Spike (IN3) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3525 | SARS Spike (CT) antibody (pAb) | Rabbit Anti-SARS Virus Membrane Protein | 100 µg |
| PK-AB718-3525P | SARS Spike (CT) peptide | Viral SARS Spike (CT) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3527 | SARS M (NT) antibody (pAb) | Rabbit Anti-SARS Virus Membrane Protein | 100 µg |
| PK-AB718-3527P | SARS M (NT) peptide | Viral SARS M (NT) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3529 | SARS M (CT) antibody (pAb) | Rabbit Anti-SARS Virus Membrane Protein | 100 µg |
| PK-AB718-3529P | SARS M (CT) peptide | Viral SARS M (CT) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3531 | SARS E (NT) antibody (pAb) | Rabbit Anti-SARS Virus Envelope Protein | 100 µg |
| PK-AB718-3531P | SARS E (NT) peptide | Viral SARS E (NT) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3533 | SARS E (CT) antibody (pAb) | Rabbit Anti-SARS Virus Envelope Protein | 100 µg |
| PK-AB718-3533P | SARS E (CT) peptide | Viral SARS E (CT) Antibody Blocking Peptide | 50 µg |
ACE2 Antibodies & Blocking Peptides
| PK-AB718-3215 | ACE2 (IN1) antibody (pAb) | Rabbit Anti-Human/Mouse Angiotensin Converting Enzyme 2 (SARS Receptor) | 100 µg |
| PK-AB718-3215P | ACE2 (IN1) peptide | Human ACE2 (IN1) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3217 | ACE2 (CT) antibody (pAb) | Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) | 100 µg |
| PK-AB718-3217P | ACE2 (CT) peptide | Human ACE2 (CT) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3227 | ACE2 (NT) antibody (pAb) | Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) | 100 µg |
| PK-AB718-3227P | ACE2 (NT) peptide | Human ACE2 (NT) Antibody Blocking Peptide | 50 µg |
| PK-AB718-3229 | ACE2 (IN2) antibody (pAb) | Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) | 100 µg |
| PK-AB718-3229P | ACE2 (IN2) peptide | Human ACE2 (IN2) Antibody Blocking Peptide | 50 µg |
Related Products
Moreover, we supply a huge variety of Cytokines & Growth Factors as well as the corresponding ELISAs & Antibodies for Immunology/Innate Immunity (e.g. to detect cytokine storm and acute inflammation).
In addition, PromoCell provides a wide range of assays to study Cell Health & Viability , Oxidative Stress, Cell Metabolism & Signaling and Cell Migration & Phagocytosis.
Please visit also our page summarizing our respiratory cell culture tools for COVID-19 research.
Please note: All products are for research use only and not for in vitro-diagnostic or therapeutic purposes.