Study and fight Coronavirus with research tools from PromoCell

The rapidly spreading Coronavirus Disease – known as COVID-19 – is not only threatening peoples’ health and lives but also worldwide mobility and the economy. To support the efforts of researchers worldwide to study, understand and combat this new health threat, PromoCell offers a range of high-quality antibodies specifically directed against components of the SARS-CoV-2 and the ACE2 receptor.

COVID-19 is caused by a novel Coronavirus (CoV) called SARS-CoV-2, also known as 2019-nCoV. The disease outbreak was first discovered in Wuhan, China but has spread to many other countries with up-to-date millions of laboratory-confirmed infections and several hundred thousand of fatal cases. The World Health Organization (WHO) has declared a global health emergency to gather resources and remedy this threat.

Background

There are four coronavirus genera: alpha-coronavirus, beta-coronavirus, gamma-coronavirus, and delta-coronavirus. SARS-CoV-2 belongs to the beta-coronavirus genus originating from bats. Beta-coronaviruses can infect mammals, are zoonotic pathogens, and can cause severe respiratory disease in humans.

Other viruses in this family are SARS coronavirus (SARS-CoV) and MERS coronavirus. SARS-CoV-2 has approximately 79% sequence identity to SARS-CoV and 50% to MERS-CoV which gives us clues as to how it may infect and cause disease in humans. In addition, homology modeling shows SARS-CoV-2 has a similar receptor-binding domain structure as SARS-CoV which suggests SARS-CoV-2 uses the angiotensin-converting enzyme-2 (ACE2) receptor in humans for infection. A significant amount of research has already been done to understand ACE2 and how it may be used as a host receptor by viruses, giving us a head-start when fighting COVID-19.

The ACE2 SARS-CoV-2 Interaction

ACE2 is expressed in the human heart, lung, kidney and gastrointestinal tract and is an essential regulator of heart function and blood pressure. ACE2 is a functional receptor, acting as the entry point into human lung cells for both SARS-CoV and the human respiratory coronavirus (HCoV-NL63). This makes it a potential target for therapy that could prevent COVID-19 infection.
Research into the interaction between SARS-CoV-2 and ACE2 (→ binding of the viral Spike S1 protein to the ACE2 receptor) is key as this dynamic is crucial to understanding both cross-species and human to human transmissions of COVID-19.

Tools to Study COVID-19

SARS-CoV-2-Receptor

To support the efforts of researchers worldwide to study, understand and combat this new health threat, PromoCell offers a range of high-quality antibodies specifically directed against components of the SARS-CoV-2 and the ACE2 receptor as well as several fine chemicals identified as potential inhibitors of SARS-CoV.

As ACE2 is a potential therapeutic target not only for cardiovascular disorders but also for coronavirus-induced diseases, we also provide an ACE2 Activity Assay as well as an ACE Inhibitor Screening Assay and an SARS-CoV-2/ACE Binding Inhibitor Screening Kit to further support research progress in this field.

Recent studies have shown that inhibitors of the cellular Furin protease, which is essential for the formation of the functional viral Spike (S) Protein (and thus SARS-CoV-2 virus entry and replication), are potential antiviral agents to counteract SARS-CoV-2 infection and pathogenesis. Our Furin Activity Assay Kit and Furin Inhibitor Screening Kit are useful tools to develop new targeted therapeutics for Covid-19.

Please note: All products are for research use only and not for in vitro-diagnostic or therapeutic purposes.

Product list

Assays

PK-CA577-K2050 SARS-CoV-2/ACE Binding Inhibitor Screening Kit Rapid, simple and sensitive colorimetric assay to screen for potential inhibitors of SARS-Cov S1 protein binding to human ACE2. 100 assays
PK-CA577-K897 ACE2 Activity Assay Kit Fast and simple fluorometric detection of Angiotensin I Converting Enzyme activity in tissue/cell lysates. 100 assays
PK-CA577-K310 ACE2 Inhibitor Screening Kit  Simple fluorometric assay that can be used to identify and characterize Angiotensin II Converting Enzyme inhibitors/activators in a high-throughput format. 100 assays
PK-CA577-K2076 Furin Activity Assay Kit A quick and sensitive fluorometric assay to determine Furin activity in various samples. 100 assays
PK-CA577-K2069 Furin Inhibitor Screening Kit A quick and sensitive fluorometric assay for screening, studying and characterizing potential Furin inhibitors 100 assays

ACE2 Antibodies & Blocking Peptides

PK-AB577-2072A ACE2 antibody (pAb) Rabbit Anti-ACE2 100 µg
PK-AB718-3215 ACE2 (IN1) antibody (pAb) Rabbit Anti-Human/Mouse Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3215P ACE2 (IN1) peptide Human ACE2 (IN1) Antibody Blocking Peptide 50 µg
PK-AB718-3217 ACE2 (CT) antibody (pAb) Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3217P ACE2 (CT) peptide Human ACE2 (CT) Antibody Blocking Peptide 50 µg
PK-AB718-3227 ACE2 (NT) antibody (pAb) Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3227P ACE2 (NT) peptide Human ACE2 (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3229 ACE2 (IN2) antibody (pAb) Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3229P ACE2 (IN2) peptide Human ACE2 (IN2) Antibody Blocking Peptide 50 µg

SARS Antibodies & Blocking Peptides

PK-AB718-3219 SARS Spike (NT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3219P SARS Spike (NT) peptide Viral SARS Spike (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3221 SARS Spike (IN1) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3221P SARS Spike (IN1) peptide Viral SARS Spike (IN1) Antibody Blocking Peptide 50 µg
PK-AB718-3223 SARS Spike (IN2) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3223P SARS Spike (IN2) peptide Viral SARS Spike (IN2) Antibody Blocking Peptide 50 µg
PK-AB718-3225 SARS Spike (IN3) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3225P SARS Spike (IN3) peptide Viral SARS Spike (IN3) Antibody Blocking Peptide 50 µg
PK-AB718-3525 SARS Spike (CT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3525P SARS Spike (CT) peptide Viral SARS Spike (CT) Antibody Blocking Peptide 50 µg
PK-AB718-9083 SARS-S1 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Spike S1 100 µg
PK-AB718-9083B SARS-S1 antibody (pAb), biotin Rabbit Anti-SARS-CoV-2 (COVID-19) Spike S1 (biotinylated) 100 µg
PK-AB718-9083P SARS-S1 peptide SARS-S1 Blocking Peptide 50 µg
PK-AB718-9087 SARS-S-RBD antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Spike RBD 100 µg
PK-AB718-9087B SARS-S-RBD antibody (pAb), biotin Rabbit Anti-SARS-CoV-2 (COVID-19) Spike RBD (biotinylated) 100 µg
PK-AB718-9087P SARS-S-RBD peptide SARS-S-RBD Blocking Peptide 50 µg
PK-AB718-9091 SARS-S antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Spike (cleavage site) 100 µg
PK-AB718-9091B SARS-S antibody (pAb), biotin Rabbit Anti-SARS-CoV-2 (COVID-19) Spike, cleavage site (biotinylated) 100 µg
PK-AB718-9091P SARS-S peptide SARS-S Blocking Peptide 50 µg
PK-AB718-9095 SARS-S antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Spike (cleavage site) 100 µg
PK-AB718-9095P SARS-S peptide SARS-S Blocking Peptide 50 µg
PK-AB718-9119 SARS-S2 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Spike S2 100 µg
PK-AB718-9119P SARS-S2 peptide SARS-S2 Blocking Peptide 50 µg
PK-AB718-9123 SARS-S2 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Spike S2 100 µg
PK-AB718-9123B SARS-S2 antibody (pAb), biotin Rabbit Anti-SARS-CoV-2 (COVID-19) Spike S2 (biotinylated) 100 µg
PK-AB718-9123P SARS-S2 peptide SARS-S2 Blocking Peptide 50 µg
PK-AB577-2103A SARS-CoV S1 antibody (mAb) Human Anti-SARS-CoV/CoV-2 (COVID-19) S1 Spike Protein 200 µg
PK-AB577-3000A SARS-CoV S1 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) S1 Spike Protein 50 µg
PK-AB577-3001A SARS-CoV S1 antibody (mAb) Mouse Anti-SARS-CoV-2 (COVID-19) S1 Spike Protein 50 µg
PK-AB718-3531 SARS E (NT) antibody (pAb) Rabbit Anti-SARS Virus Envelope Protein 100 µg
PK-AB718-3531P SARS E (NT) peptide Viral SARS E (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3533 SARS E (CT) antibody (pAb) Rabbit Anti-SARS Virus Envelope Protein 100 µg
PK-AB718-3533P SARS E (CT) peptide Viral SARS E (CT) Antibody Blocking Peptide 50 µg
PK-AB718-9169 SARS-E antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Envelope 100 µg
PK-AB718-9099 SARS-N antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Nucleocapsid 100 µg
PK-AB718-9099B SARS-N antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Nucleocapsid (biotinylated) 100 µg
PK-AB718-9099P SARS-N peptide SARS-N Blocking Peptide 50 µg
PK-AB718-9103 SARS-N antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Nucleocapsid 100 µg
PK-AB718-9103B SARS-N antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Nucleocapsid (biotinylated) 100 µg
PK-AB718-9103P SARS-N peptide SARS-N Blocking Peptide 50 µg
PK-AB718-3527 SARS M (NT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3527P SARS M (NT) peptide Viral SARS M (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3529 SARS M (CT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3529P SARS M (CT) peptide Viral SARS M (CT) Antibody Blocking Peptide 50 µg
PK-AB718-9157 SARS-M antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Membrane 100 µg
PK-AB718-9165 SARS-M antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Membrane 100 µg
PK-AB577-2060A SARS-CoV NP antibody (mAb) Mouse Anti-SARS-CoV-2 (COVID-19) Nucleoprotein 50 µg
PK-AB577-2061A SARS-CoV NP antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) Nucleoprotein 50 µg
PK-AB577-2063A SARS-CoV NP antibody (mAb) Mouse Anti-SARS-CoV/CoV-2/MERS (COVID-19) Nucleoprotein 100 µg
PK-AB577-2064A SARS-CoV NP antibody (mAb) Mouse Anti-SARS-CoV/CoV-2 (COVID-19) Nucleoprotein 100 µg
PK-AB577-2066A SARS-CoV NP antibody (mAb) Mouse Anti-SARS-CoV/CoV-2 (COVID-19) Nucleoprotein 100 µg
PK-AB577-2092A SARS-CoV NP antibody (mAb) Mouse Anti-SARS-CoV-2 (COVID-19) Nucleoprotein 50 µg
PK-AB577-2093A SARS-CoV NP antibody (mAb) Mouse Anti-SARS-CoV-2 (COVID-19) Nucleoprotein 50 µg
PK-AB718-9151 SARS-NSP5 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) 100 µg
PK-AB718-9153 SARS-NSP5 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) 100 µg
PK-AB718-9155 SARS-NSP7 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP7 100 µg
PK-AB718-9159 SARS-NSP8 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP8 100 µg
PK-AB718-9161 SARS-NSP9 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP9 100 µg
PK-AB718-9163 SARS-NSP9 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP9 100 µg
PK-AB718-9167 SARS-NSP8 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP8 100 µg
PK-AB718-9171 SARS-NSP2 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP2 100 µg
PK-AB718-9173 SARS-NSP2 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP2 100 µg
PK-AB718-9175 SARS-NSP4 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP4 100 µg
PK-AB718-9177 SARS-NSP6 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP6 100 µg
PK-AB718-9179 SARS-NSP10 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP10 100 µg
PK-AB718-9181 SARS-NSP13 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP13 100 µg
PK-AB718-9183 SARS-NSP13 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP13 100 µg
PK-AB718-9185 SARS-NSP14 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP14 (ExoN) 100 µg
PK-AB718-9187 SARS-NSP14 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) NSP14 (ExoN) 100 µg
PK-AB718-9189 SARS-ORF6 antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) ORF6 Protein 100 µg
PK-AB718-9191 SARS-ORF9b antibody (pAb) Rabbit Anti-SARS-CoV-2 (COVID-19) ORF9b Protein 100 µg
PK-AB577-2065A MERS-CoV S1 antibody (mAb) Mouse Anti-MERS-CoV S1 Spike Protein 100 µg
PK-AB577-2067A MERS-CoV S1 antibody (mAb) Mouse Anti-MERS-CoV S1 Spike Protein 100 µg

Biochemicals for SARS-Covid Research

PK-CA577-9687-100 / -500 ACE2 Inhibitor DX600 100 µg / 500 µg / 1 mg
PK-CA577-B2726-1 / -5 ACE-2 Substrate (fluorogenic) 1 mg / 5 mg
PK-CA577-B2717-1 / -5 ACE-2 Substrate MCA-YVADAPK(Dnp)-OH 1 mg / 5 mg
PK-CA577-B2141-5 / -25 Amprenavir 5 mg / 25 mg
PK-CA577-B1129-5 / -25 Apilimod mesylate 5 mg / 25 mg
PK-CA577-4690-5 / -100 Aprotinin 5 mg / 100 mg
PK-CA577-B3050-5 / -25 Astemizole 5 mg / 25 mg
PK-CA577-B1901-5 / -25 Atazanavir 5 mg / 25 mg
PK-CA577-2234-5 / -25 AZD6244 5 mg / 25 mg
PK-CA577-B1506-250 / -1000 Calpain Inhibitor Z-LLY-FMK 250 µg / 1 mg
PK-CA577-1125-20C Calpain Inhibitor Z-LLY-FMK (10 mM) 20 µl
PK-CA577-B2145-5 / -25 Camostat mesylate 5 mg / 25 mg
PK-CA577-B3042-10 / -50 Cepharanthine 10 mg / 50 mg
PK-CA577-1825-100 / -500 Chloroquine Diphosphate 100 mg / 500 mg
PK-CA577-B1992-100 / -500 Chlorpromazine Hydrochloride 100 mg / 500 mg
PK-CA577-B2091-25 / -100 Concanamycin A 25 µg / 100 µg
PK-CA577-1041-1G / -5G Cycloheximide 1 g / 5 g
PK-CA577-1041-1 Cycloheximide (100 mM) 1 ml
PK-CA577-1522-100 / -1G Cyclosporine A 100 mg / 1 g
PK-CA577-1042-1G / -10G Dexamethasone  1 g / 10 g
PK-CA577-1042-1 Dexamethasone (10 mM) 1 ml
PK-CA577-2308-50 / -250 Disulfiram 50 mg / 250 mg
PK-CA577-2169-5 / -25 Ebselen 5 mg / 25 mg
PK-CA577-1970-50 /-250 Emetine dihydrochloride 50 mg / 250 mg
PK-CA577-1875-25 / -100 Emodin 25 mg / 100 mg
PK-CA577-1917-5 / -25 Everolimus 5 mg / 25 mg
PK-CA577-B3043-5 / -25 GBR-12909 5 mg / 25 mg
PK-CA577-1960-1 / -5 GSK-1120212 1 mg / 5 mg
PK-CA577-7004-10 GSK-3β, human, recombinant 10 µg
PK-CA577-B2051-50 / -250 Hydroxychloroquine sulfate 50 mg / 250 mg
PK-CA577-2141-100 / -1G Imatinib 100 mg / 1 g
PK-CA577-2240-50 / -250 Linagliptin 50 mg / 250 mg
PK-CA577-2241-50 / -250 Lopinavir 50 mg / 250 mg
PK-CA577-2195-10 / -50 MDL 28170 10 mg / 50 mg
PK-CA577-B2705-5 / -25 Merimepodib 5 mg / 25 mg
PK-CA577-1703-5 / -25 MG-132 5 mg / 25 mg
PK-CA577-1882-50 / -250 Mycophenolic Acid 50 mg / 250 mg
PK-CA577-1760-10 / -50 Nafamostat Mesylate 10 mg / 50 mg
PK-CA577-B2142-5 / -25 Nefinavir mesylate hydrate 5 mg / 25 mg
PK-CA577-1826-100 / -500 Niclosamide 100 mg / 500 mg
PK-CA577-B3052-500 / -1G Omeprazole 500 mg / 1 g
PK-CA577-1732-25 / -100 Pepstatin A 25 mg / 100 mg
PK-CA577-B2681-10 / -50 Reserpine 10 mg / 50 mg
PK-CA577-1758-100 / -500 Resveratrol 100 mg / 500 mg
PK-CA577-2199-10 / -50 Ribavirin 10 mg / 50 mg
PK-CA577-B3051-5 / -25 RIPA-56 5 mg / 25 mg
PK-CA577-B2140-10 / -50 Ritonavir 10 mg / 50 mg
PK-CA577-B1999-10 / -50 Saquinavir mesylate 10 mg / 50 mg
PK-CA577-1582-5 / -25 Saracatinib (AZD0530) 5 mg / 25 mg
PK-CA577-B2722-5 / -25 SSAA09E1 5 mg / 25 mg
PK-CA577-B2723-1 / -5 SSAA09E2 1 mg / 5 mg
PK-CA577-1645-1 SU5402 1 mg
PK-CA577-2238-10 / -50 Valinomycin 10 mg / 50 mg
PK-CA577-B2039-50 / -250 6-Mercaptopurine 50 mg / 250 mg

Related Products

Moreover, we supply a huge variety of Cytokines & Growth Factors as well as the corresponding ELISAs & Antibodies for Immunology/Innate Immunity (e.g. to detect cytokine storm and acute inflammation).

In addition, PromoCell provides a wide range of assays to study Cell Health & Viability , Oxidative Stress, Cell Metabolism & Signaling and Cell Migration & Phagocytosis.

Please visit also our page summarizing our respiratory cell culture tools for COVID-19 research.

Please note: All products are for research use only and not for in vitro-diagnostic or therapeutic purposes.

Promotion

Use the promotion code PK-AB-1/20 when purchasing on our webshop one of the above listed products:
- SARS Antibodies and Blocking Peptides
- ACE2 Antibodies and Blocking Peptides
- ACE Assay Kits

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