Can the Primary Cancer Culture System (PCCS) be used to establish cell lines from PDX mouse models? Will mouse cells be eliminated during the process?

Yes. The isolation of human cancer cells from patient-derived xenograft (PDX) mouse models is a key application of the Primary Cancer Culture System (PCCS).
PCCS supports the selective recovery and expansion of malignant human cancer cells while minimizing the growth of non-malignant mouse cells, including mouse fibroblasts. This facilitates the establishment of human cancer cell cultures from PDX tissue and helps prevent overgrowth by murine stromal cells.