Which endothelial cell type is recommended for studying atherosclerosis?

Atherosclerosis primarily affects arteries and is characterized by the formation of lipid-rich plaques within the vessel wall. For atherosclerosis research, PromoCell offers several arterial endothelial cell types, including:

• Human Coronary Artery Endothelial Cells (HCAEC) for studies focused on coronary artery disease
• Human Aortic Endothelial Cells (HAoEC) for investigations of large-vessel atherosclerosis

Please note: The choice of endothelial cell type should reflect the vascular region and disease model of interest, as endothelial cells from different vascular beds may exhibit distinct biological responses.
 
In addition to endothelial cells, vascular smooth muscle cells (SMCs) play a critical role in atherosclerosis development and progression. Increasing evidence suggests that phenotypic switching of SMCs into alternative cell states is a key driver of plaque formation, progression, and complications. Depending on the study objectives, the use of arterial SMCs (HAoSMC, HCASMC) alone or in co-culture with endothelial cells may therefore provide a more comprehensive model of atherogenesis.
Our Scientific Support team will be happy to assist you in selecting the most suitable cell types for your specific atherosclerosis model.