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Traditional cell culture systems often fall short of replicating the complex environment of the human airway, limiting their predictive power in respiratory research. To address these limitations, researchers increasingly rely on physiologically relevant in vitro models that better reflect human airway biology. Among these, air-liquid interface (ALI) culture bridges the gap between simple two-dimensional systems and complex animal models, offering a human-based approach for studying respiratory function and disease in vitro.

Implementing a qualified supply chain for GMP-compliant cell culture products is a crucial step toward meeting the highest quality standards. In this interview with RegMedNet, our experts share insights into the supply chain requirements that must comply with GMP regulations for cell culture products.

Not all cancer cells within a single tumor have the same characteristics. The tumor microenvironment contains various subsets of cancer cells. The characteristics of each subgroup can influence tumor growth, metastasis, and treatment resistance. Read on to learn how these cellular differences affect cancer progression and treatment outcomes.

The traditional view of macrophages as ‘good’ or ‘bad’ immune cells has become outdated. Recent studies have shown that macrophage plasticity encompasses a complex spectrum of activation states, each of which plays an important role in health and disease. In this article, we discuss the latest understanding of macrophage polarization, the challenges in standardizing nomenclature, and why standardization is important for the development of new therapeutic approaches.

The Human Leukocyte Antigen (HLA) system is a set of genes that play important roles in health and disease, serving as a flag for ‘self’ and ‘non-self’ cells. As such, HLA molecules have implications in several biomedical research areas, from immunology to transplantation and precision medicine. In this article, we explore what HLA typing is, why it matters, and how HLA research is shaping our understanding of autoimmune diseases, infectious diseases, stem cell transplantation, and cancer.

The use of mesenchymal stem cells in regenerative medicine is a scientific success story that started approximately 40 years ago. Although mesenchymal stem cells were initially met with skepticism, they now form the foundation of thousands of research studies and hundreds of clinical trials. In this article, we discuss how the origin of mesenchymal stem cells may impact their properties and therapeutic potential.